58316-39-5Relevant academic research and scientific papers
Synthesis of isocoumarins via silver(I)-mediated annulation of enol esters
Panda, Niranjan,Mishra, Priyadarshini,Mattan, Irshad
, p. 1047 - 1056 (2016/02/19)
Silver-mediated annulation of 2-iodo enol esters leading to 4- and 3,4-substituted isocoumarins was accomplished selectively at room temperature. Coupling of 2-iodo benzoic acids with enolates that were produced in situ from the simple esters was also performed to produce isocoumarins under analogous reaction conditions. Owing to the mildness of the current protocol, 4-acyl 3-substituted isocoumarins were efficiently produced without any deacylation.
Reactions of 3,4-Dihydroisoquinolines with Enol Esters Derived from β-Ketoesters
Akhrem, A. A.,Borisov, E. V.,Chernov, Yu. G.
, p. 1132 - 1136 (2007/10/03)
1-(1-Ethoxycarbonyl-2-oxopropyl)-2-acyltetrahydroisoquinolines were synthesized by reaction of 3,4-dihydroisoquinolines with 3-acyloxy-2-butenoates.In a similar way, reactions of 6,7-dimethoxy-3,4-dihydroisoquinoline with 3-acyloxy-2-pentenedioates yield mixtures of 2-(2-acyl-6,7-dimethoxytetrahydroisoquinolin-1-yl)-3-oxopentanedioates and 2,4-bis(2-acyl-6,7-dimethoxytetrahydroisoquinolin-1-yl)-3-oxopentanedioates.According to 1H NMR spectra, the compounds prepared exist in CDCl3 as an equilibrium mixture of isomers.A possible mechanism of transformation is discussed.
