51751-37-2

Basic information

• Product Name: 2-methyl-4-oxo-4H-chromene-3-carboxylic acid
• CAS NO: 51751-37-2
• Molecular Formula: C₁₁H₈O₄
• Molecular Weight: 204.1788
• Mol File: 51751-37-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 341.4°C at 760 mmHg
• Flash Point: 136.5°C
• Density: 1.405g/cm³
• Vapor Pressure: 3.11E-05mmHg at 25°C
• Refractive Index: 1.612
• CAS DataBase Reference: 2-methyl-4-oxo-4H-chromene-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-4-oxo-4H-chromene-3-carboxylic acid(51751-37-2)
• EPA Substance Registry System: 2-methyl-4-oxo-4H-chromene-3-carboxylic acid(51751-37-2)

Safety Data

• Hazardous Substances Data: 51751-37-2(Hazardous Substances Data)

Upstream product

• 67140-88-9 2-Methyl-4-oxo-4H-<1>benzopyran-3-carbonitrile 
• 20349-86-4 Methyl 3-(2-hydroxy-phenyl)-3-oxopropanoate 
• 1076-38-6 4-hydroxy[1]benzopyran-2-one 
• 58316-39-5 (E)-4-ethoxy-4-oxobut-2-en-2-yl benzoate 
• 41492-27-7 (E)-4-oxopent-2-en-2-yl benzoate 
• 51751-33-8 methyl 2-methylchromone-3-carboxylate 
• 1441-87-8 salicyloyl chloride 
• 118-93-4 o-hydroxyacetophenone 
• 39208-08-7 ethyl 3-<2-(benzyloxy)phenyl>-3-oxopropanoate 
• 31165-67-0 2'-benzyloxyacetophenone 
• 10037-20-4 3-acetyl-2-methyl-4-oxo-4H-<1>benzopyran 
• 1694-31-1 tert-butyl acetoacetate 
• 393-52-2 2-Fluorobenzoyl chloride 
• 74555-98-9 ethyl 2-methyl-4-oxo-4H-1-benzopyran-3-carboxylate 

Downstream Products

• 51751-33-8 methyl 2-methylchromone-3-carboxylate 
• 124557-95-5 1-phenyl-5-(4-hydroxy-2-oxo-1-benzopyran-3-yl)-pyrazole 
• 83344-79-0 11-methoxy-7,8,9,10-tetrahydrobenzoxanthene-12-one 
• 83344-78-9 11-hydroxy-7,8,9,10-tetrahydrobenzoxanthene-12-one 
• 2764-19-4 3-methyl-1-phenyl-1H,4H-chromeno[4,3-c]pyrazol-4-(1H)one 
• 51138-49-9 5-(2-hydroxyphenyl)-3-methylisoxazole 
• 86100-07-4 3-methyl-2-phenylchromeno[4,3-c]pyrazol-4(2H)-one 
• 51138-45-5 1-phenyl-3-methyl-5-(2'-hydroxyphenyl)pyrazole 
• 5751-48-4 2-methylchromone 
• 16636-62-7 1-(2'-hydroxyphenyl)butane-1,3-dione 

Relevant articles and documents

Access to chromone-3-carboxylic acid via silver mediated coupling of 4-hydroxy coumarin and enol ester

A silver-mediated aerobic approach to access 2-methyl-chromone-3-carboxylic acid from the reaction of 4-hydroxy coumarin and enol ester in the presence of base has been presented. Mechanistic investigation suggests that the base induced Michael-type addition reaction of 4-hydroxy coumarin to the enol ester resulting the sequential ring opening and closing with the liberation of acetone are the key-steps for the overall transformation. Theoretical calculation of energy of the intermediates by DFT supports the proposed reaction mechanism.

An Improved Synthesis of 2-Methylchromone-3-carboxylic Acid and its Esters

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Substituted chromone-3-carbonitriles, carboxamides and carboxylic acids useful for preventing asthmatic symptoms

Substituted chromone-3-carbonitriles, carboxamides and carboxylic acids having the structural formula: SPC1 Wherein R1 represents hydrogen, halogen, lower alkyl, hydroxy, lower alkoxy, or acyloxy; R2 represents hydrogen, lower alkyl, fluorinated lower alkyl, alkoxycarbonyl, carboxy, or lower alkyl carboxylic acid; Z represents cyano, carboxy, alkoxycarbonyl, or EQU1 wherein X represents amino, N-lower-alkylamino, hydroxylamino, N-lower-alkylhydroxylamino, ureido, piperidino, or anilino, with the proviso that when R2 represents hydrogen, Z represents cyano or EQU2 wherein X has the same meaning as given above; and wherein R2 and Z together may form a substituted pyrrole ring; and the corresponding non-toxic, pharmaceutically acceptable salts.