58358-37-5

Upstream product

• 64-17-5 ethanol 
• 16213-85-7 (2,5-dimethylphenyl)acetonitrile 
• 186581-53-3 diazomethane 
• 22328-43-4 2,5-dimethylbenzoyl chloride 
• 77928-08-6 ethyl α-methylthio-2,4-dimethylphenylacetate 
• 106-42-3 para-xylene 
• 824-45-3 2,5-dimethylbenzyl chloride 
• 553-94-6 4-bromo-m-xylene 
• 610-72-0 2,5-dimethylbenzoic acid 
• 53957-33-8 2,5-dimethylbenzyl alcohol 
• 95-92-1 oxalic acid diethyl ester 
• 623-73-4 diazoacetic acid ethyl ester 
• 55312-97-5 2-(2,5-dimethylphenyl)acetyl chloride 
• 589-18-4 4-Methylbenzyl alcohol 

Downstream Products

• 6972-51-6 2-(2,5-dimethylphenyl)ethan-1-ol 
• 83026-40-8 diethyl (2,5-dimethylphenyl)propanedioate 
• 105077-02-9 diethyl α-methylthio-2,5-dimethyl-1,4-benzenediacetate 
• 28081-38-1 2-(2',5'-dimethylphenyl)ethyl bromide 
• 13612-34-5 2-(2,5-dimethylphenyl)acetic acid 
• 53806-66-9 diethyl 2,5-dimethyl-1,4-benzenediacetate 

Relevant academic research and scientific papers

Synthesis method and application of 1, 3-bis(2, 5-dimethylphenyl)propan-2-one

The invention discloses a synthesis method of 1, 3-bis(2, 5-dimethylphenyl)propan-2-one. The method includes: taking 2, 5-dimethylphenylacetic acid as the raw material, carrying out acylation and ethyl esterification reaction to obtain the intermediate et

Aromatic Claisen Rearrangements of Benzyl Ketene Acetals: Conversion of Benzylic Alcohols to (ortho-Tolyl)acetates

Claisen rearrangements of benzyl vinyl ethers are much less facile than those of aliphatic allyl vinyl ethers, and their synthetic utility has remained relatively unexplored. A one-pot procedure is reported for the generation and Claisen rearrangement of benzyl vinyl ethers that contain an activating α-alkoxy substituent on the vinyl group. A [3,3]-sigmatropic mechanism was supported by trapping of the intermediate isotoluene in an intramolecular Alder–ene reaction.

Iron and manganese catalysts for the selective functionalization of arene C(sp2)-H bonds by carbene insertion

The first examples of the direct functionalization of non-activated aryl sp2 C-H bonds with ethyl diazoacetate (N2CHCO2Et) catalyzed by Mn- or Fe-based complexes in a completely selective manner are reported, with no formation of the frequently observed cycloheptatriene derivatives through competing Buchner reaction. The best catalysts are FeII or MnII complexes bearing the tetradentate pytacn ligand (pytacn= 1-(2-pyridylmethyl)-4,7-dimethyl-1,4,7-triazacyclononane). When using alkylbenzenes, the alkylic C(sp3)-H bonds of the substituents remained unmodified, thus the reaction being also selective toward functionalization of sp2 C-H bonds. Exclusive catalysis: Iron- and-manganese-based catalysts selectively functionalize the C(sp2)-H bonds of benzene or alkylbenzenes through the formal insertion of the CHCO2Et group from N2CHCO2Et (see scheme). When using alkylbenzenes, the alkylic C(sp3)-H bonds of the substituents remain unmodified.

Synthesis of arylacetates from benzylic alcohols and oxalate esters through decarboxylative coupling

Follow that dream: By combining a reversible transesterification between benzylic alcohols and dialkyl oxalates with catalytic decarboxylation of the resulting esters, a regiospecific C-C-bond-forming reaction to give α-arylacetates was achieved. In the overall process, CO2 and a volatile alcohol are the only byproducts. Various α-arylacetates were thus synthesized in high yields from easily accessible starting materials in the presence of catalytic amounts of Pd(OAc)2, dppp, and DABCO (see scheme). Copyright

AMINO ACID DERIVATIVES AND THEIR USE AS THROMBIN INHIBITORS

There is provided compounds of formula I, wherein R 1, R 2, R 3, R x, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in particular in the treatment of conditions where inhibition of thrombin is required as in thrombosis or as anticoagulants.

Syntheses of Arenediacetic Esters and Acetonyl-Substituted Arylacetic Esters by Means of Friedel-Crafts Reaction with α-Acyl-α-chlorosulfides

Friedel-Crafts reaction of the phenylacetates 5a, b with ethyl α-chloro-α-(methylthio)acetate (1) in the presence of stannic chloride gave the α-methylthio-1,4-benzenediacetates 7a, b.The reactions of biphenyl, diphenylmethane, and diphenyl ether with an excess amount of 1 gave directly the corresponding disubstituted products 10a-c.Desulfurization of 7a, b and 10a-c gave the corresponding diacetates 8a, b and 11a-c.Methyl 4-(2-oxopropyl)phenylacetate (14) was prepared by reaction of methyl phenylacetate with α-chloro-α-(methylthio)acetone (2) followed by desulfurization of the resulting product.Methyl 2-(2-furyl)propionate (19) reacted with 2 in the presence of zinc chloride to give the 2,5-disubstituted furan 20, whose desulfurization gave methyl 2-propionate (21).Keywords - arenediacetic ester; Friedel-Crafts reaction; α-chlorosulfide; nonactic acid; nonactin; desulfurization; Raney nickel; stannic chloride; zinc chloride