58358-45-5

Upstream product

• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 868-85-9 Dimethyl phosphite 
• 873-76-7 para-Chlorobenzyl alcohol 
• 121-45-9 phosphorous acid trimethyl ester 
• 622-95-7 4-chlorobenzyl bromide 
• 186581-53-3 diazomethane 
• 154197-03-2 bis(4-methoxyphenyl) 4-chlorobenzylphosphonate 
• 154197-00-9 3-cyano-4'-methoxybiphenyl 

Downstream Products

• 78022-15-8 1-(4-Chlorostyryl)-4-(2-cyanostyryl)benzene 
• 147137-69-7 4-chlorobenzylphosphonyl dichloride 
• 154197-07-6 methyl 4-chlorobenzylphosphonyl chloride 
• 154702-26-8 methyl dimethoxyphosphoryl(4-chlorophenyl)acetate 
• 60754-01-0 2-[(E)-2-(4-Chloro-phenyl)-1-methyl-vinyl]-1,3,5-trimethyl-benzene 
• 60753-99-3 C₁₅H₁₂BrCl 
• 60754-00-9 C₁₅H₁₂ClNO₂ 
• 617714-57-5 3-(4-Chloro-benzylidene)-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester 
• 154197-03-2 bis(4-methoxyphenyl) 4-chlorobenzylphosphonate 
• 154196-94-8 4-methoxyphenyl methyl 4-chlorobenzylphosphonate 
• 181575-52-0 methyl p-chlorobenzylphosphonate 
• 60753-98-2 1-((E)-1-(4-chlorophenyl)prop-1-en-2-yl)benzene 

Relevant academic research and scientific papers

Tetrahydroquinolinyl phosphinamidates and phosphonamidates enhancing tolerance towards drought stress in crops via interaction with ABA receptor proteins

New phosphorous-containing lead structures against drought stress in crops interacting with RCAR/(PYR/PYL) receptor proteins were identified starting from in-depth SAR studies of related sulfonamide lead structures and protein docking studies. A converging 6-step synthesis via phosphinic chlorides and phosphono chloridates as key intermediates afforded envisaged tetrahydroquinolinyl phosphinamidates and phosphonamidates. Whilst tetrahydroquinolinyl phosphonamidates 13a,b exhibited low to moderate target affinities, the corresponding tetrahydroquinolinyl phosphinamidates 12a,b revealed confirmed strong affinities for RCAR/ (PYR/PYL) receptor proteins in Arabidopsis thaliana on the same level as essential plant hormone abscisic acid (ABA) combined with promising efficacy against drought stress in vivo (broad-acre crops wheat and canola).

Palladium-catalyzed benzylic substitution of benzyl carbonates with phosphorus nucleophiles

A wide range of benzyl carbonates reacted with dimethyl phosphonate or diphenylphosphine oxide in the presence of the palladium catalyst, [Pd(η3-allyl)Cl]2DPEphos, to give dimethyl benzylphosphonates and benzyldiphenylphosphine oxides in high yields. The catalytic phosphonylation was applied to the one-pot synthesis of alkenes from the benzyl esters.

Palladium(II)-catalyzed ortho-arylation of benzylic phosphonic monoesters using potassium aryltrifluoroborates

The new monophosphonic acid directing group was successfully utilized in the Pd (II)-catalyzed ortho-arylation of benzylic phosphonic monoesters using potassium aryltrifluoroborates. A wide range of benzylic phosphonic monoesters underwent clean ortho-ary

Bridged bicyclic amine derivatives useful as CCR-3 receptor antagonists

Compounds having the formula (I), Ar—(F)(E)-(CR3R4)—(CHR5)m-(T)-(Q)-Ar1, are useful as CCR-3 receptor antagonists, wherein T is a bridged heterocyclyl group having one N atom and a bridge of one to two bridgehead carbon atoms; Ar and Ar1 are aryl or heteroaryl; F is alkylene, alkenylene, or a bond; E is —C(═O)N(R10)—, —SO2N(R10)—, —N(R11)C(═O)N(R10O)—, —N(R11)SO2N(R10)—, —N(R11)C(═S)N(R10)—, —N(R11)C(═O)—, —N(R11)SO2—, —N(R12)C(═O)CH(R13)—, or CH(R13)C(═O)N(R12)—; Q is —C(═O)— or C1-2alkylene; and R3, R4, R5, R9, R10, R11, R12, and R13 are defined as set forth in the specification.

Photolysis of 4-Methoxyphenyl Aryl Alkylphosphonates

UV irradiation of bis(4-methoxyphenyl) methylphosphonate 1a in methanol gave 4,4'-dimethoxybiphenyl 2a as the main product through an intramolecular excimer.With 4-cyanophenyl-4-methoxyphenyl methylphosphonate 1b 4-cyano-4'-methoxybiphenyl 2c and 4-cyano-2-(4'-methoxyphenyl)phenyl methylphosphonate 4b were obtained through an intramolecular exciplex. 3-Cyanophenyl-4-methoxyphenyl methyl phosphonate 1c gave only 3-cyano-4'-methoxybiphenyl 2f.Methyl 4-methoxyphenyl 4-chlorobenzylphosphonate 5a gave dimethyl 4-chlorobenzyl 2-(4'-methoxyphenyl)phosphonate and dimethyl 2-(4'-methoxyphenyl)benzylphosphonate.

SYMMETRICAL AND UNSYMMETRICAL DERIVATIVES OF DISTYRYLBENZENE

The symmetrically substituted derivatives I-V of 1,4-distyrylbenzene have been prepared via the Horner reaction.A modification of the latter enabled preparation of unsymmetrical derivatives of 1,4-distyrylbenzene.