58373-59-4

Basic information

• Product Name: N-(2,4-Dichlorophenyl)benzenamine
• Synonyms: 2,4-Dichlorophenyl-N-phenylamine;2,4-Dichlorophenylphenylamine;N-(2,4-Dichlorophenyl)benzenamine
• CAS NO: 58373-59-4
• Molecular Formula: C₁₂H₉Cl₂N
• Molecular Weight: 238.11
• Mol File: 58373-59-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(2,4-Dichlorophenyl)benzenamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,4-Dichlorophenyl)benzenamine(58373-59-4)
• EPA Substance Registry System: N-(2,4-Dichlorophenyl)benzenamine(58373-59-4)

Safety Data

• Hazardous Substances Data: 58373-59-4(Hazardous Substances Data)

Usage

General Description

N-(2,4-Dichlorophenyl)benzenamine is a chemical compound with the formula C12H9Cl2N. It is an aromatic amine that is commonly used in the synthesis of pharmaceuticals, dyes, and other organic compounds. It is a white to off-white crystalline solid with a melting point of 69-72°C and a boiling point of 332.6°C. N-(2,4-Dichlorophenyl)benzenamine is an important intermediate in the production of a wide range of chemicals and is also used in the manufacturing of pesticides and herbicides. It must be handled with care as it is considered hazardous if ingested, inhaled, or in contact with the skin, and proper protective measures should be taken when working with this compound.

Upstream product

• 18201-58-6 N-(2,4-dichloro-phenyl)-anthranilic acid 
• 13246-96-3 2,4-Dichlorophenoxyacetanilide 
• 626239-02-9 2-Chloro-N-(2,4-dichloro-phenyl)-N-phenyl-acetamide 
• 626239-03-0 N-(2,4-dichloro-phenyl)-2-hydroxy-N-phenyl-acetamide 
• 554-00-7 2,4-Dichloroaniline 
• 118-91-2 ortho-chlorobenzoic acid 
• 98-80-6 phenylboronic acid 
• 639-58-7 triphenyltin chloride 
• 2592-95-2 benzotriazol-1-ol 

Downstream Products

• 70172-31-5 diclofenac 
• 626239-03-0 N-(2,4-dichloro-phenyl)-2-hydroxy-N-phenyl-acetamide 
• 13246-96-3 2,4-Dichlorophenoxyacetanilide 
• 575-90-6 2,6-dichlorophenoxyacetic acid 

Relevant articles and documents

Peptide Nanofiber Templated Zinc Oxide Nanostructures as Non-precious Metal Catalyzed N-Arylation of Amines, One-Pot Synthesis of ImidazoHeterocycles and Fused Quinazolines

In the present study, peptide nanofiber was used to immobilize zinc oxide. This nanoparticle was prepared through self-assembly in an aqueous solution. The structural properties of the prepared catalyst were examined by a series of techniques, such as FT-IR, EDS, SEM, TEM, XRD, ICP-OES (inductively coupled plasma optical emission spectrometry), and ultraviolet–visible (UV–Vis) spectroscopy. TEM images showed the necklace model for peptide nanofiber decorated with zinc oxide. The versatility of the method was investigated by N-arylation using reaction of amines with hydroxybenzotriazole as a novel phenylating reagent, one-pot synthesis of imidazoheterocycles by a three-component reaction of 2-aminopyridine, aldehyde, terminal alkyne and preparation of tetracyclic quinazolinone ring by one-pot reaction of isatoic anhydride, amine, and ninhydrin. High yields, low cost of catalyst, environmental friendliness, efficient recovery and recyclability of catalyst are the most important features of this catalytic system.

Practical copper-catalyzed N-arylation of amines with 20% aqueous solution of n-Bu4NOH

N-Arylation of a wide variety of amines with phenylboronic acid catalyzed by copper acetate under 20% aqueous solution of n-Bu4NOH was accomplished in good to excellent yields (up to 92%) and substrate conversions (up to 96%).