583873-82-9

Upstream product

• 583873-81-8 tert-butyl 4-(4-methyl-2-(methylsulfanyl)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzoate 
• 18144-47-3 tert-butyl 4-aminobenzoate 
• 344361-90-6 5-ethoxycarbonyl-6-methyl-2-methylsulfanylpyrimidin-4(3H)-one 
• 583878-42-6 ethyl 4-chloro-6-methyl-2-(methylthio)pyrimidine-5-carboxylate 
• 1462-12-0 diethyl ethylidenemalonate 
• 642455-54-7 tert-butyl 4-{[5-[(1E)-3-ethoxy-3-oxo-1-propenyl]-6-methyl-2-(methylsulfanyl)-4-pyrimidinyl]amino}benzoate 
• 583878-43-7 ethyl 4-[4-(tert-butoxycarbonyl)anilino]-6-methyl-2-(methylsulfanyl)-5-pyrimidinecarboxylate 
• 583878-44-8 tert-butyl 4-{[5-(hydroxymethyl)-6-methyl-2-(methylsulfanyl)-4-pyrimidinyl]amino}benzoate 
• 583878-45-9 tert-butyl 4-{[5-formyl-6-methyl-2-(methylsulfanyl)-4-pyrimidinyl]amino}benzoate 

Downstream Products

• 583873-84-1 tert-butyl 4-(4-methyl-7-oxo-2-(4-phenyl-1-piperazinyl)pyrido[2,3-d]pyrimidin-8(7H)-yl)benzoate 
• 583873-83-0 tert-butyl 4-(2-[4-(ethoxycarbonyl)anilino]-4-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)benzoate 
• 583873-90-9 4-(4-methyl-7-oxo-2-(4-phenyl-1-piperazinyl)pyrido[2,3-d]pyrimidin-8(7H)-yl)benzoic acid 
• 583878-47-1 4-(4-methyl-7-oxo-2-(4-phenyl-1-piperazinyl)pyrido[2,3-d]pyrimidin-8(7H)-yl)benzoyl chloride 

Relevant academic research and scientific papers

Solid-phase synthesis of pyrido[2,3-d]pyrimidin-7-ones

A novel solid-phase method for the synthesis of 4-methyl-pyrido[2,3-d] pyrimidin-7-one compounds with two diversity points is described. The polymer supported methylsulfonyl derivatives A3, achieved by coupling compound G with different resin-bound amines A1 followed by oxidation with MCPBA, are substituted with several amines R1R2NH. Final cleavage affords 126 compounds having formula H in good yield and purity.

Pyridopyrimidinones derivatives as telomerase inhibitors

The invention provides novel pyrido[2,3-d]pyrimidin-7(8H)-ones derivatives active as telomerase inhibitors, the use of the derivatives as therapeutic agents, such as antitumoral agents, processes for preparation of the derivatives, and to pharmaceutical compositions comprising the derivatives.