583883-85-6

Basic information

• Product Name: Acetic acid, [4-[[(dimethylamino)carbonyl]thio]-2-methylphenoxy]-, methyl ester
• CAS NO: 583883-85-6
• Molecular Formula: C13H17NO4S
• Molecular Weight: 283.348
• Mol File: 583883-85-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Acetic acid, [4-[[(dimethylamino)carbonyl]thio]-2-methylphenoxy]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, [4-[[(dimethylamino)carbonyl]thio]-2-methylphenoxy]-, methyl ester(583883-85-6)
• EPA Substance Registry System: Acetic acid, [4-[[(dimethylamino)carbonyl]thio]-2-methylphenoxy]-, methyl ester(583883-85-6)

Safety Data

• Hazardous Substances Data: 583883-85-6(Hazardous Substances Data)

Upstream product

• 317319-09-8 (4-acetoxy-2-methylphenoxy)acetic acid methyl ester 
• 166953-80-6 (4-acetyl-2-methylphenoxy)acetic acid methyl ester 
• 317319-10-1 methyl (4-hydroxy-2-methylphenoxy)acetate 
• 876-02-8 4-hydroxy-3-methylphenyl methyl ketone 

Downstream Products

• 317318-84-6 GW 0742 
• 317318-67-5 {2-methyl-4-[4-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-5-ylmethylsulfanyl]-phenoxy}-acetic acid methyl ester 
• 317318-69-7 methyl [2-methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]thiazol-5-yl]methyl]sulfanyl]peroxy]acetate 
• 56077-47-5 (4-mercapto-2-methyl-phenoxy)-acetic acid methyl ester 

Relevant articles and documents

Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ) - Synthesis and biological activity

We report the synthesis and biological activity of a new series of small molecule agonists of the human Peroxisome Proliferator-Activated Receptor δ (PPARδ). Several hits were identified from our original libraries containing lipophilic carboxylic acids. Optimization of these hits by structure-guided design led to 7k (GW501516) and 7l (GW0742), which shows an EC50 of 1.1 nM against PPARδ with 1000-fold selectivity over the other human subtypes.