317318-69-7

Basic information

• Product Name: GW 501516 Methyl Ester
• Synonyms: GW 501516 Methyl Ester
• CAS NO: 317318-69-7
• Molecular Formula: C₂₂H₂₀F₃NO₃S₂
• Molecular Weight: 467.5243096
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
• Mol File: 317318-69-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 93-95?C
• Boiling Point: 553.8±60.0 °C(Predicted)
• Appearance: /
• Density: 1.36±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Dichloromethane (Slightly), Ethyl Acetate (Slightly)
• PKA: 1.92±0.10(Predicted)
• CAS DataBase Reference: GW 501516 Methyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: GW 501516 Methyl Ester(317318-69-7)
• EPA Substance Registry System: GW 501516 Methyl Ester(317318-69-7)

Safety Data

• Hazardous Substances Data: 317318-69-7(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Solid

Uses

Precursor to GW 501516.

Upstream product

• 96-32-2 bromoacetic acid methyl ester 
• 636589-63-4 4-{{2-[4-(trifluoromethyl)phenyl]-4-methylthiazol-5-yl}methylthio}-2-methylphenol 
• 3774-53-6 2-methyl-4-thiocyanato-phenol 
• 175277-03-9 4-methyl-2-[4-(trifluoromethyl)phenyl]thiazole-5-carboxylic acid ethyl ester 
• 583883-85-6 (4-dimethylcarbamoylsulfanyl-2-methyl-phenoxy)-acetic acid methyl ester 
• 583883-84-5 (4-dimethylthiocarbamoyloxy-2-methyl-phenoxy)-acetic acid methyl ester 
• 317319-09-8 (4-acetoxy-2-methylphenoxy)acetic acid methyl ester 
• 166953-80-6 (4-acetyl-2-methylphenoxy)acetic acid methyl ester 
• 317319-10-1 methyl (4-hydroxy-2-methylphenoxy)acetate 
• 72505-21-6 4-trifluoromethylbenzthioamide 
• 876-02-8 4-hydroxy-3-methylphenyl methyl ketone 
• 95-48-7 ortho-cresol 
• 32281-01-9 4-mercapto-2-methylphenol 
• 317318-96-0 [4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-methanol 

Relevant articles and documents

A Short and Efficient Synthesis of the Pharmacological Research Tool GW501516 for the Peroxisome Proliferator-Activated Receptor δ

The most potent and selective peroxisome proliferator-activated receptor δ (PPARδ) agonist GW501516 (1) was synthesized in 4 steps and 78% overall yield starting from o-cresol by using a one-pot regiocontrolled dialkylation of mercaptophenol 5 as the key

Activator of PPAR delta

Compounds of Formula (I) are disclosed. These compounds include selective activators of human PPAR delta.