58399-75-0

Upstream product

• 134454-62-9 (E)-methyl 2-((3aR,5S,6aR)-2,2-dimethyl-5-((trityloxy)methyl)furo[2,3-d][1,3]dioxol-6-(3aH,5H,6aH)-ylidene)acetate 
• 20590-54-9 1,2-O-isopropylidene-5-O-(triphenylmethyl)-α-D-erythro-pentofuranos-3-ulose 
• 532-20-7 D-xylofuranose 
• 20590-53-8 1,2-O-isopropylidene-5-O-trityl-α-D-xylofuranose 
• 20031-21-4 1,2-O-isopropylidene-α-D-xylose 
• 5927-18-4 trimethyl phosphonoacetate 
• 76-83-5 trityl chloride 

Downstream Products

• 58399-76-1 3-Deoxy-3-C-(2'-hydroxyethyl)-1,2-O-isopropylidene-5-O-(triphenylmethyl)-α-D-ribofuranose 

Relevant academic research and scientific papers

ANTIBODY-STING AGONIST CONJUGATES AND THEIR USE IN IMMUNOTHERAPY

The present disclosure relates to, among other things, antibody-drug conjugates comprising a STING agonist cyclic di-nucleotide conjugated to an antibody, preparation methods therefor, and uses therefor.

CYCLIC DI-NUCLEOTIDE COMPOUNDS AND METHODS OF USE

Disclosed are cyclic-di-nucleotide cGAMP analogs, methods of synthesizing the compounds, pharmaceutical compositions comprising the compounds thereof, and use of compounds and compositions in medical therapy.

11-Oxa-prostaglandin analogs

The invention provides compounds of the formula 1 which are useful as hypertensive, anti-ulcer, anti-asthmatic and nasal decongestant agents and methods of preparing these compounds: STR1 wherein A represents --C=O or α--C . . . OH B represents STR2 Rsub