5840-09-5

Upstream product

• 19788-30-8 4-nitroso-N-ethylaniline 
• 7647-01-0 hydrogenchloride 
• 612-64-6 N-ethyl-N-nitrosoaniline 
• 1826-56-8 N-ethyl-N-(4-nitrophenyl)acetamide 
• 106-50-3 1,4-phenylenediamine 
• 1222062-40-9 2-[(4-ethylaminophenylamino)methylene]malonic acid diethyl ester 
• 100-01-6 4-nitro-aniline 
• 529-65-7 N-ethylacetanilide 
• 945-81-3 N-nitroso N-ethyl-N-(4-nitroaniline) 

Downstream Products

• 1111628-58-0 1-[2,3-di(tert-butoxycarbonyl)guanidino]-4-(N-ethyl)benzene 
• 1111628-53-5 2-(4-ethylamino-phenylimino)-imidazolidine-1,3-dicarboxylic acid di-tert-butyl ester 
• 1615250-76-4 N-[1,3-di(tert-butoxycarbonyl)-4-(fur-2-yl)imidazolidin-2-ylidene]-4-ethylaminoaniline 
• 1615250-74-2 2-[(4-ethylaminophenyl)imino]-5-methyl-1,3-di(tert-butoxycarbonyl)imidazolidine 
• 1615250-69-5 1-[1-(tert-butoxycarbonyl)-3-phenylguanidino]-4-ethylaminobenzene 
• 1615250-67-3 1-[1-(tert-butoxycarbonyl)-3-(4-ethylaminophenyl)guanidino]ethyl acetate 
• 1615250-65-1 1-[1-(tert-butoxycarbonyl)-3-(furan-2-ylmethyl)guanidino]-4-ethylaminobenzene 
• 57838-84-3 N-[2-(4-Ethylamino-phenylamino)-5-hydroxy-4-methyl-phenyl]-acetamide 
• 56330-27-9 N-{6-[(Z)-4-Ethylamino-phenylimino]-4-methyl-3-oxo-cyclohexa-1,4-dienyl}-acetamide 

Relevant academic research and scientific papers

a2-Adrenoceptor Ligands

The adrenergic receptors or adrenoceptors are a family of G-protein coupled receptors split into α and β subclasses. The adrenoceptors have important roles in regulating a myriad of physiological conditions and their malfunction has been implicated in the pathophysiology of a number of diseases. Disclosed herein are a series of novel compounds which are ligands of the alpha2-adrenoceptor (α2-ARs) subclass of adrenergic receptors. The invention also provides for pharmaceutical compositions comprising the novel compounds. The compounds are suitable for use in the manufacture of medicaments for the treatment of α2-ARs associated disorders, such as depression and schizophrenia.

2,2-Bis(ethoxycarbonyl)vinyl (BECV) as a versatile amine protecting group for selective functional-group transformations

A 2,2-Bis(ethoxycarbonyl) vinyl- (BECV) group was used for the selective protection of amines at room temperature in the presence of potentially interfering functional groups such as OH, SH, COOH as well as other NH 2 groups. Several functional group transformations such as esterification, O-alkylation, O-acylation, N-alkylation, N-acylation, S-alkylation can selectively be carried out in the presence of the BECV group. The selective deprotection of the BECV group was achieved in a short time using ethylenediamine at room temperature while several other functional groups such as benzoate, aliphatic esters, amides and ethers remain intact. The BECV group shows orthogonal stability against the common protecting groups such as Fmoc, Cbz and Boc.

Guanidine and 2-aminoimidazoline aromatic derivatives as α2-adrenoceptor ligands: Searching for structure-activity relationships

In this paper, we report the synthesis of three new 2-aminoimidazoline (compounds 4b, 5b, and 6b) and three new guanidine derivatives (compounds 7b, 8b, and 9b) as potential α2-adrenoceptor antagonists for the treatment of depression. Their pha

Reduction of nitrosoarenes into anilines by Al/NH4Cl in refluxing methanol

A simple, cost-effective method for the reduction of nitrosoarenes by aluminium in the presence of ammonium chloride in refluxing methanol to give anilines is reported.