1826-56-8

Usage

Uses

Used in Pharmaceutical Industry:
N-ETHYL-4'-NITROACETANILIDE is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its role in the development of new drugs and the production of organic materials makes it a valuable component in this industry.
Used in Organic Chemistry:
N-ETHYL-4'-NITROACETANILIDE is used as a building block in the synthesis of other organic chemicals. Its versatility in chemical reactions contributes to the creation of a wide range of compounds for various applications.
It is important to handle N-ETHYL-4'-NITROACETANILIDE with care, as it is considered hazardous and may pose health risks if not handled properly.

InChI:InChI=1/C10H12N2O3/c1-3-11(8(2)13)9-4-6-10(7-5-9)12(14)15/h4-7H,3H2,1-2H3

Upstream product

• 529-65-7 N-ethylacetanilide 
• 3665-80-3 N-Ethyl-4-nitroanilin 
• 108-24-7 acetic anhydride 
• 104-04-1 N-(4-Nitrophenyl)acetamide 
• 75-03-6 ethyl iodide 
• 7697-37-2 nitric acid 
• 7664-93-9 sulfuric acid 
• 75-36-5 acetyl chloride 
• 350-46-9 4-Fluoronitrobenzene 

Downstream Products

• 3665-80-3 N-Ethyl-4-nitroanilin 
• 5840-09-5 4-amino-1-(N-ethylamino)benzene 
• 2051-82-3 acetic acid-(N-ethyl-4-amino-anilide) 

Relevant academic research and scientific papers

A Facile Oxidation of Tertiary Amines to Lactams by Using Sodium Chlorite: Process Improvement by Precise pH Adjustment with CO 2

By using cheap and innocuous sodium chlorite, a series of tertiary amines have been oxidized to the corresponding lactams with good selectivity and high yield. In this method, neither transition-metal catalyst nor oxidant was used. In the oxidation step, the pH of the sodium chlorite was precisely adjusted to pH around 6 using CO2, such pH is a compromise between oxidative properties, chemical stability, and unwanted precipitation. In addition, buffer salts are not necessary, which allows this oxidation reaction to be performed under safe and environmentally benign conditions.

Regioselective nitration of anilines with Fe(NO3)3·9H2O as a promoter and a nitro source

An efficient Fe(NO3)3·9H2O promoted ortho-nitration reaction of aniline derivatives has been developed. This reaction may go through a nitrogen dioxide radical (NO2) intermediate, which is generated by the thermal decomposition of iron(iii) nitrate. The practicality of the present method using nontoxic and inexpensive iron reagents has been shown by the broad substrate scope and applications.

Purine derivatives inhibitors of tyrosine protein kinase SYK

Disclosed are compounds of the formula in free or salt form, wherein X, R1, R2, R3, and R4are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment o