25283-96-9

Basic information

• Product Name: 5-Methyl-3-(4-nitrophenyl)-1,2,4-oxadiazole
• Synonyms: 5-Methyl-3-(4-nitrophenyl)-1,2,4-oxadiazole;3-(p-Nitrophenyl)-5-methyl-1,2,4-oxadiazole
• CAS NO: 25283-96-9
• Molecular Formula: C₉H₇N₃O₃
• Molecular Weight: 205.17018
• Mol File: 25283-96-9.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 376.5 °C at 760 mmHg
• Flash Point: 181.5 °C
• Appearance: /
• Density: 1.349 g/cm³
• CAS DataBase Reference: 5-Methyl-3-(4-nitrophenyl)-1,2,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methyl-3-(4-nitrophenyl)-1,2,4-oxadiazole(25283-96-9)
• EPA Substance Registry System: 5-Methyl-3-(4-nitrophenyl)-1,2,4-oxadiazole(25283-96-9)

Safety Data

• Hazardous Substances Data: 25283-96-9(Hazardous Substances Data)

Usage

General Description

5-Methyl-3-(4-nitrophenyl)-1,2,4-oxadiazole is a chemical compound with the molecular formula C9H7N3O3. It is a derivative of oxadiazole, a five-membered heterocyclic compound containing one oxygen and two nitrogen atoms. 5-Methyl-3-(4-nitrophenyl)-1,2,4-oxadiazole is mainly used in organic synthesis and pharmaceutical applications due to its potential biological activities including antimicrobial, cytotoxic, and antitumor properties. It is often utilized as a precursor in the synthesis of various pharmaceutical drugs and agrochemicals. 5-Methyl-3-(4-nitrophenyl)-1,2,4-oxadiazole is a yellow crystalline solid with a high melting point and is considered to be stable under normal conditions. It is important for potential users to handle this compound with care due to its potential hazardous nature.

Upstream product

• 127-19-5 N,N-dimethyl acetamide 
• 192332-48-2 N'-hydroxy-4-nitrobenzimidamide 
• 64-19-7 acetic acid 
• 141-78-6 ethyl acetate 
• 75-05-8 acetonitrile 
• 192332-48-2 (Z)-4-nitrobenzamidoxime 
• 937-31-5 (4-Nitrophenyl)acetylene 
• 555-16-8 4-nitrobenzaldehdye 
• 75-36-5 acetyl chloride 
• 1613-86-1 N-hydroxy-4-nitrobenzamidine 
• 108-24-7 acetic anhydride 
• 619-72-7 4-nitrobenzonitrile 
• 1613-86-1 p-nitrophenylamidoxime 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 10185-68-9 4-(5-methyl-1,2,4-oxadiazol-3-yl)-aniline 

Relevant articles and documents

Thermal transformation of arylamidoximes in the presence of phosphorus ylides. Unexpected formation of 3-aryl-5-arylamino-1,2,4-oxadiazoles

The unexpected formation of 3-aryl-5-arylamino-1,2,4-oxadiazoles took place, when arylamidoximes reacted thermally with ethoxycarbonylmethylene(triphenyl)phosphorane. Furoxans, nitriles, ureas were also isolated suggesting aryl cyanide oxides as intermedi

The reaction of amidoximes with carboxylic acids or their esters under high-pressure conditions

3,5-Disubstituted 1,2,4-oxadiazoles were synthesized by the reaction of amidoximes with carboxylic acids or their esters under high-pressure conditions (10 kbar). The reaction proceeds without the use of other reagents or catalysts. Both aliphatic and aro

Reaction of amidoximes with acetonitrile at high pressure

Reaction of amidoximes with acetonitrile giving 1,2,4-oxadiazoles occurs at 80-100 °C under a pressure of 10 Kbar without catalysts.