5845-26-1Relevant academic research and scientific papers
Asymmetric Hydrogenation of Vinylthioethers: Access to Optically Active 1,5-Benzothiazepine Derivatives
Li, Wei,Schlepphorst, Christoph,Daniliuc, Constantin,Glorius, Frank
, p. 3300 - 3303 (2016/03/22)
A novel asymmetric hydrogenation of vinylthioethers was developed using a ruthenium(II) NHC complex. This method provides an efficient approach to optically active 1,5-benzothiazepines featuring stereocenters with C-S bonds. Excellent enantioselectivities
A 1,5-benzothiazepine synthesis
Phippen, Christopher B.W.,McErlean, Christopher S.P.
supporting information; experimental part, p. 1490 - 1492 (2011/05/16)
The pharmaceutically active compound (±)-thiazesim was synthesized in four steps and 62% overall yield. This new approach to biologically relevant benzothiazepine ring systems features the use of water as a solvent, co-solvent or catalyst in three of the
