58457-98-0

Basic information

• Product Name: (S)-Methyl 2-N-Cbz-3-N-Boc-propanoate
• Synonyms: (S)-METHYL 2-N-CBZ-3-N-BOC-PROPANOATE;3-[[(1,1-Dimethylethoxy)carbonyl]amino]-N-[(phenylmethoxy)carbonyl]-L-alanine methyl ester;3-(Boc-amino)-N-Cbz-L-alanine methyl ester
• CAS NO: 58457-98-0
• Molecular Formula: C₁₇H₂₄N₂O₆
• Molecular Weight: 352.38
• Product Categories: Amino Acids & Derivatives;Chiral Reagents
• Mol File: 58457-98-0.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 514.325 °C at 760 mmHg
• Flash Point: 264.855 °C
• Appearance: /
• Density: 1.177
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.513
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (S)-Methyl 2-N-Cbz-3-N-Boc-propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-Methyl 2-N-Cbz-3-N-Boc-propanoate(58457-98-0)
• EPA Substance Registry System: (S)-Methyl 2-N-Cbz-3-N-Boc-propanoate(58457-98-0)

Safety Data

• Hazardous Substances Data: 58457-98-0(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Methyl 2-(S)-[N-[(Benzyloxy)carbonyl]amino-3-[N-[t-butyloxycarbonyl)amino]-propionate (cas# 58457-98-0) is a compound useful in organic synthesis.

InChI:InChI=1/C17H24N2O6/c1-17(2,3)25-15(21)18-10-13(14(20)23-4)19-16(22)24-11-12-8-6-5-7-9-12/h5-9,13H,10-11H2,1-4H3,(H,18,21)(H,19,22)/t13-/m0/s1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 35761-27-4 methyl (2S)-3-amino-2-{[(benzyloxy)carbonyl]amino}propanoate hydrochloride 
• 501-53-1 benzyl chloroformate 
• 2304-96-3 N-benzyloxycarbonyl-L-asparagine 
• 1333506-14-1 benzyl N-[(1S)-1-(furan-2-yl)-2-nitroethyl]carbamate 
• 75-09-2 dichloromethane 
• 159002-15-0 (S)-2-(benzyloxycarbonylamino)-3-(tert-butoxycarbonylamino)propionoic acid 
• 74-88-4 methyl iodide 
• 74536-29-1 (S)-2-amino-3-((tert-butoxycarbonyl)amino)propanoic acid 
• 16947-86-7 N^α-Tosyl-N^β-(tert-butpxycarbonyl)-L-α,β-diamonopropionic acid 
• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 23632-66-8 (4S)-3-benzyloxycarbonyl-4-carboxymethyl-1,3-oxazolidin-5-one 
• 35761-26-3 (S)-3-amino-2-(((benzyloxy)carbonyl)amino)propanoic acid 
• 75760-11-1 (S)-methyl 3-amino-2-(((benzyloxy)carbonyl)amino)propanoate 

Downstream Products

• 1384613-21-1 C₁₆H₂₃N₃O₈S 
• 1384613-17-5 C₁₅H₂₁N₃O₈S 
• 16947-84-5 N-[(benzyloxy)carbonyl]-3-[(tert-butoxycarbonyl)amino]-L-alanine 
• 35761-27-4 methyl (2S)-3-amino-2-{[(benzyloxy)carbonyl]amino}propanoate hydrochloride 
• 138093-74-0 (S)-2-Benzyloxycarbonylamino-3-(tert-butoxycarbonyl-methyl-amino)-propionic acid methyl ester 
• 138093-73-9 2-benzyloxycarbonylamino-3-methylamino-propionic acid methyl ester 
• 138093-86-4 N^α-(benzyloxycarbonyl)-N^β-(tert-butoxycarbonyl)-N^β-methyl-L-α,β-diaminopropionylglycyl-N⁵,N⁸-bis(tert-butoxycarbonyl)spermidine 
• 130581-75-8 N^α-(benzyloxycarbonyl)-N^β-(tert-butoxycarbonyl)-N^β-methyl-L-α,β-diaminopropionic acid 
• 77087-65-1 (S)-2-({(R)-1-[(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-3-phenyl-propionyl]-pyrrolidine-2-carbonyl}-amino)-3-tert-butoxycarbonylamino-propionic acid 2,4,5-trichloro-phenyl ester 
• 77087-64-0 methyl N-(benzyloxycarbonyl)glycyl-L-phenylalanyl-D-prolyl-N^β-(tert-butoxycarbonyl)-L-α,β-diaminopropanoate 
• 77087-66-2 (S)-2-({(R)-1-[(S)-2-(2-Amino-acetylamino)-3-phenyl-propionyl]-pyrrolidine-2-carbonyl}-amino)-3-tert-butoxycarbonylamino-propionic acid 2,4,5-trichloro-phenyl ester 
• 77100-18-6 cyclo(glycyl-L-phenylalanyl-D-prolyl-N^β-(tert-butoxycarbonyl)-L-α,β-diaminopropanoyl) 
• 126046-29-5 (S)-3-tert-Butoxycarbonylamino-2-((S)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-propionic acid methyl ester 
• 126046-28-4 (S)-3-tert-Butoxycarbonylamino-2-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-propionic acid methyl ester 

Relevant articles and documents

Sulfate Encapsulation in Supramolecular Structures from L -Asparagine-Derived 2,5-Diketopiperazine Scaffolds: Anion Binding

We report a new sulfate receptor, anchored onto 2,5-diketopiperazine units, which results in the formation of two types of supramolecules; one in which the sulfate ion guest fits snugly into extended cavities and the other in which the guest is sandwiched between layers. In each case, the anion is held by six hydrogen bonds from the host. 1H NMR spectroscopic solution studies enabled the construction of Job plots, and calculation of stoichiometry and association constants. These findings are of possible significance in drug design and for construction of combinatorial libraries.

ETHER DERIVATIVE

The present invention relates to an ether derivative represented by the formula (I), a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof wherein each symbol is as defined in the description, and an ether derivative represented by the formula (III), a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof wherein each symbol is as defined in the description; a pharmaceutical composition containing the ether derivative; and a package containing the pharmaceutical composition and a description of use thereof. A pharmaceutical composition of the present invention, which contains this compound of the present invention has a superior anti-inflammatory and analgesic activity and is useful as various pharmaceutical agents such as an anti-inflammatory agent, an analgesic, a therapeutic agent for inflammatory bowel disease, a therapeutic agent for pollakiuria and/or incontinentia, a therapeutic agent for asthma and the like.

MODULATORS OF CELLULAR ADHESION

The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1-R4, n, p, A, B, D, E, L and AR1 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of disorders mediated by the CD11/CD18 family of cellular adhesion molecules (e.g., LFA-1).