58475-16-4

Upstream product

• 4005-46-3 3-deoxy-1,2-O-isopropylidene-D-glucose 
• 98-59-9 p-toluenesulfonyl chloride 
• 72605-81-3 1,2-O-isopropylidene-3-O-(methylthio)thiocarbonyl-α-D-glucofuranose 
• 16667-96-2 1,2,5,6-di-O-isopropylidene-α-D-glucofuranose-3-O-(S-methylxanthate) 
• 582-52-5 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose 
• 22248-87-9 (R)-1-((3aR,5S,6aR)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)ethane-1,2-diol 
• 75824-57-6 5,6-di-O-acetyl-1,2-O-isopropylidene-3-O-(methylthio)thiocarbonyl-α-D-glucofuranose 
• 4613-62-1 3-deoxy-1,2;5,6-di-O-isopropylidene-α-D-glucofuranoside 
• 74707-99-6 5,6-Di-O-acetyl-3-deoxy-1,2-O-isopropylidene-α-D-ribo-hexofuranose 

Downstream Products

• 23655-60-9 (2S,3R,5S)-5-((S)-1,2-diacetoxyethyl)tetrahydrofuran-2,3-diyl diacetate 
• 169392-07-8 [(1S,2R)-2-Benzyloxy-1-((R)-2,2,5,5-tetramethyl-[1,3]dioxolan-4-ylmethyl)-propoxy]-tert-butyl-dimethyl-silane 
• 169392-05-6 (4S,6R)-4-((R)-1-Benzyloxy-ethyl)-6-(bis-ethylsulfanyl-methyl)-2,2-dimethyl-[1,3]dioxane 
• 284031-48-7 1,4-dideoxymannojirimycin 
• 284031-35-2 1,3,6-trideoxy-1,6-imino-D-ribo-hexitol 
• 82087-33-0 3,5-Didesoxy-1,2-O-isopropyliden-6-O-(p-tosyl)-α-D-erythro-hexofuranose 
• 316804-22-5 3-deoxy-1,2-O-isopropylidene-5-O-(thiocarbonylimidazolyl)-6-O-tosyl-α-D-ribo-hexofuranose 

Relevant academic research and scientific papers

TLR7 AGONISTS

The present invention relates to TLR7 agonists according to Formula I and their use in the treatment of diseases such as cancer and infectious disease.

THE TOTAL SYNTHESIS OF GLUCOSEPANE AND COMPOUNDS OBTAINED THEREFROM

Glucosepane is a structurally complex protein post-translational modification (PTM) believed to exist in all living organisms. Research in humans suggests that glucosepane plays a critical role in the pathophysiology of both diabetes and human aging; yet

COMBINATION THERAPY OF AN HBSAG INHIBITOR AND A TLR7 AGONIST

The present invention is directed to compositions and methods for treating hepatitis B virus infection. In particular, the present invention is directed to a combination therapy comprising administration of an HBs Ag inhibitor and a TLR7 agonist for use i

NOVEL 3-SUBSTITUTED 5-AMINO-6H-THIAZOLO[4,5-D]PYRIMIDINE-2,7-DIONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION

The present invention relates to compounds of formula (I), wherein R1, R2 and R3 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

COMBINED TREATMENT WITH A TLR7 AGONIST AND AN HBV CAPSID ASSEMBLY INHIBITOR

The present invention is directed to compositions and methods for treating hepatitis B virus infection. In particular, the present invention is directed to a combination therapy comprising administration of a TLR7 agonist and an HBV capsid assembly inhibi

Syntheses of sugar-related trihydroxyazepanes from simple carbohydrates and their activities as reversible glycosidase inhibitors

Five diastereomeric trideoxy-1,6-iminohexitols were synthesised, and their inhibitory activities were determined against selected glycosidases. For comparison, 1,4,5-trideoxy-1,5-imino-D-lyxo-hexitol, the 4-deoxy derivative of 1-deoxymannojirimicin, was prepared by enzymatic isomerisation of 6-azido-3,6-dideoxy-D-ribo-hexose into the corresponding 2-ulose and subsequent hydrogenation accompanied by intramolecular reductive amination. (C) 2000 Elsevier Science Ltd.

Synthesis of kanamycin A analogs containing a 6-amino-6-deoxyglycofuranose moiety

Three kanamycin A analogs containing 6-amino-6-deoxyglycofuranoses have been prepared as candidates for potential activity against resistant bacteria producing 6'-N-acetyltransferase. They are 4-O-(6-amino-3,5,6-trideoxy-α-D-, -β-D-, and -β-L-erythro-hexofuranosyl)-6-O-(3-amino-3-deoxy-α-D-glucopyran osyl)-2,5-dideoxy-5-epi-5-fluorostreptamine. Structure-activity relationships of these compounds are discussed. (C) 2000 Published by Elsevier Science Ltd.

Two New 7-Geranyloxycoumarins from the Bark of Aegle Marmelos, an Indonesian Medicinal Plant

Two new 7-geranyloxycoumarins, chloromarmin and aeglin, were isolated from the bark of Aegle marmelos, and their structures were assigned to be 7-(7-chloro-6R-hydroxy-3,7-dimethyl-2-octenyloxy)coumarin (1) and 7-coumarin (2), respectively.

Control of regioselectivity in reactions of dialkylstannylene acetals. Part I. A dramatic reversal of regioselectivity in mono-p-toluenesulfonation reactions

The regioselectivities of p-toluenesulfonation reactions of dialkylstannylene acetals obtained from a number of carbohydrate-derived terminal 1,2-diols in the absence of added nucleophiles have been explored as functions of the carbohydrate structure, the

Oxidation products of arachidonic acid I. The synthesis of methyl 8R, 11R, 15-trihydroxy-9S, 12-oxyeicosa-5Z, 13E-dienoate (19)

Diacetone glucose was converted in high yield to 3-deoxy-5-6-anhydro-1,2-0-isopropylidene-D-glucofuranose(3), which was transformed to title compound.3 Its mass spectrum confirms the structure of a naturally occurring oxidation product of arach