58483-55-9

Upstream product

• 6921-66-0 4-chloro-2-hydroxy acetophenone 
• 65-85-0 benzoic acid 
• 2420-26-0 4-chlorosalicylaldehyde 
• 20718-17-6 2-(dimethyl(oxo)-λ⁶-sulfaneylidene)-1-phenylethan-1-one 

Downstream Products

• 130779-67-8 2-benzoyl-6-chloro-coumaran-3-one 
• 1148-48-7 7-chloro-2-phenyl-4H-1-benzopyran-4-one 
• 1198005-89-8 benzoic acid 5-chloro-2-(3-ethoxycarbonylbut-3-enoyl)phenyl ester 
• 1438433-47-6 1-(4-chloro-2-hydroxyphenyl)-4-phenylbutane-1,4-dione 

Relevant academic research and scientific papers

Rh(III)-Catalyzed Aldehydic C?H Functionalization Reaction between Salicylaldehydes and Sulfoxonium Ylides

A novel aldehydic C?H functionalization reaction between salicylaldehydes and sulfoxonium ylides has been developed under rhodium(III) catalysis, affording coupling products in moderate to good yields. A plausible mechanism involving aldehydic C(sp2)?H activation by rhodium(III) and rhodium(III) catalyzed carbene insertion is also proposed. It was also found that the aldehydic C?H functionalization followed by dehydrative cyclization was able to produce flavonoids in one-pot. (Figure presented.).

Green and efficient synthesis of flavones and chromones using heteropolyacids as catalyst in glycerol

Organic solvents are required to carry out most organic transformations, which cause environmental pollution because of their low volatility. Glycerol, a side product obtained from biodiesel production, has emerged as a friendly solvent due to its advantageous properties. In this paper, an efficient procedure for the synthesis of flavones and chromones, using heteropolyacids as recyclable catalyst and glycerol as the solvent, is presented. The use of heteropolyacids as catalysts allows for excellent yields, easy separation and recovery, low environmental impact, and low cost. Glycerol can also be readily recovered and used over again. In addition, the presented method provides other advantages such as the low formation of waste and the replacement of corrosive mineral acids.

Mild and efficient organocatalytic method for the synthesis of flavones

A convenient and efficient organocatalytic procedure for the selective cyclization of 1,3-diketones to give aromatic substituted 4H-chromen-4-ones under mild reaction conditions using N-triflyl phosphoramide is described. Application of the described conditions is presented in a formal synthesis of (S)-flavanone.