58486-89-8

Upstream product

• 32282-46-5 2-phenyl-4,5-dihydro-1H-imidazole-4,5-diol 
• 89-98-5 2-chloro-benzaldehyde 
• 623-33-6 glycine ethyl ester hydrochloride 
• 5873-90-5 methyl benzimidate hydrochloride 
• 1670-14-0 benzamidine monohydrochloride 
• 105-36-2 ethyl bromoacetate 
• 459-73-4 GlyOEt*HCl 
• 7471-86-5 methyl benzimidate 
• 52900-69-3 (Z)-2-phenyl-4-(2-chlorobenzylidene)-(4H)-1,3-oxazol-5-one 

Downstream Products

• 74164-07-1 N-benzoyl-2-chloro-phenylalanine 

Relevant academic research and scientific papers

Efficient microwave-assisted synthesis and antioxidant activity of 4-arylidene-2-phenyl-1H-imidazol-5(4H)-ones

The efficient synthesis of 4-arylidene-2-phenyl-1H-imidazol-5(4H)-ones was achieved via microwaveassisted reactions of 4-arylmethylene-2-phenyloxazol-5(4H) -ones with urea in glycol. This approach provides a facile shortcut for the synthesis of this type

A practical and efficient synthesis of 2,5-disubstituted-3,5-dihydro- imidazol-4-ones from oxazolones

An alternative procedure for the synthesis of 2,5-disubstituted-3,5- dihydro-imidazol-4-ones from substituted oxazolones was evaluated. The initial oxazolone ring-opening reaction was examined with a variety of ammonia source compounds followed by the sub

Synthesis of Acylamino Acids and Acylamino Acid Amides by Simultaneous Reduction and Hydrolysis of Unsaturated 2,4-Disubstituted 2-Imidazolin-5-ones

Twelve acylamino acids (II) and two acylamino acid amides (III) have been prepared by the simultaneous reduction and hydrolysis of unsaturated 2,4-disubstituted 2-imidazolin-5-ones (I) with a mixture of zinc dust and potassium hydroxide solution.

A Convenient Synthesis of Unsaturated 2,4-Disubstituted 2-Imidazolin-5-ones

Twenty five unsaturated 2,4-disubstituted 2-imidazolin-5-ones (IV) have been prepared in 23-71percent yields by condensing aromatic aldehydes with a mixture of ethyl chloroacetate and an aromatic amidinium chloride in the presence of sodium hydrogencarbonate.Twenty three of them have also been prepared in 62-97percent yields by this method using ethyl bromoacetate instaed of the chloroacetate.Further, two unsaturated 2-imidazolin-5-ones (IV) have been prepared by these two methods using cyclohexanone (yields 33percent each) and cinnamaldehyde (yields 0 and 18percent) instead of the aromatic aldehydes.

Synthesis of Acylamino Acid Amides and Acylamino Acids via 2,4-Disubstituted 2-Imidazolin-5-ones

Unsaturated 2,4-disubstituted 2-imidazolin-5-ones (I) have been reduced with a mixture of hydriodic acid and red phosphorus in the presence of acetic anhydride to give the saturated 2,4-disubstituted 2-imidazolin-5-ones (II) which have been hydrolysed to acylamino acid amides (III) and acylamino acids (IV) with sodium hydroxide solution under different conditions.In all six acylamino acid amides (23 - 51percent yields) and four acylamino acids (26 - 65percent yields) have been prepared.One saturated 2-imidazolin-5-one, namely 2-phenyl-4-benzyl-2-imidazolin-5-one has been isolated from the reaction in 40percent yield and identified.