58491-21-7Relevant academic research and scientific papers
Single-Electron-Transfer Strategy for Reductive Radical Cyclization: Fe(CO)5 and Phenanthroline System
Hwang, Joon Young,Baek, Jong Hwa,Shin, Tae Il,Shin, Jung Ha,Oh, Jae Won,Kim, Kwang Pyo,You, Youngmin,Kang, Eun Joo
, p. 4900 - 4903 (2016)
An electron-transfer strategy using low-valent iron pentacarbonyl [Fe(CO)5] to generate radical species from alkyl iodides was achieved. A range of pyrrolidines, tetrahydrofurans, and carbocycles were synthesized via 5-exo cyclization reactions of alkyl radical intermediates generated by electron transfer from a system involving Fe(CO)5, 1,10-phenanthroline, and diisopropylamine. Moreover, tandem addition reactions with Michael acceptors were also explored. Photophysical and electrochemical studies support a mechanism that involves electron transfer from the low-valent Fe reductant to alkyl iodide.
