58494-86-3Relevant academic research and scientific papers
PPh3/I2/HCOOH: An efficient CO source for the synthesis of phthalimides
Wang, Yingying,Zhou, Yang,Lei, Min,Hou, Jinjun,Jin, Qinghao,Guo, Dean,Wu, Wanying
, p. 1180 - 1185 (2019/01/26)
A straightforward and general method has been developed for the synthesis of phthalimide derivatives from 2-iodobenzamides and PPh3/I2/HCOOH in the presence of a catalytic amount of Pd(OAc)2. The reaction results demonstrate that PPh3/I2/HCOOH is a facile, efficient and safe CO source. The whole process is carried out in toluene at 80 °C and furnishes the desired products in good to excellent yields.
NEUROACTIVE COMPOUNDS AND METHODS OF USING THE SAME
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Paragraph 00217, (2016/05/11)
The invention described herein relates generally to neuroactive compounds and compositions for the treatment psychotic disorders, methods for treating psychosis using these neuroactive compounds, and methods for screening for novel neuroactive compounds. Certain aspects are directed to a family of compounds called "finazines." Certain aspects are directed to in vivo screening methods using high-throughput behavioral assays in zebrafish.
Silver-catalyzed intramolecular cyclization of o-(1-Alkynyl)benzamides: Efficient synthesis of (1H)-isochromen-1-imines
Liu, Guannan,Zhou, Yu,Ye, Deju,Zhang, Dengyou,Ding, Xiao,Jiang, Hualiang,Liu, Hong
supporting information; experimental part, p. 2605 - 2610 (2009/12/29)
An efficient avenue for the facile and atom-economic synthesis of (1H)-isochromen-1imines has been developed, and a broad spectrum of substrates can participate in the process effectively to produce the desired products in good yields. Significantly, this is the first report of the synthesis of (1H)-isochromen-l-imines that involves a silver(I)-catalyzed, regiocontrolled intramolecular addition of the carbonyl group of the amide moiety towards an alkyne.
A convenient palladium catalyzed synthesis of symmetric biaryls, biheterocycles and biaryl chiral diamides
Goswami, Shyamaprosad,Adak, Avijit Kumar,Mukherjee, Reshmi,Jana, Subrata,Dey, Swapan,Gallagher, John F.
, p. 4289 - 4295 (2007/10/03)
A series of symmetrical diamido biaryls has been synthesized in good yield by direct homocoupling of iodoarylbenzamides by palladium-catalysis. No cross product has been isolated from the reaction mixture of two different iodoarylbenzamides under similar conditions. However, only in the case of 2-iodo-N-phenylbenzamide, the intramolecularly coupled product phenanthridone has been isolated as a minor product along with the major intermolecularly coupled product. Biphenyl chiral diamides have been synthesized by this coupling method. This coupling reaction also works well with the reductive dimerization of functionalized heterocyclic compounds. Thus 6,6′-dipivaloylamino-3, 3′-bipyridine and 6,6′-dimethyl-2,2′-bipyridine have been efficiently synthesized. In two cases, the X-ray crystal structures have been solved to establish the structures of symmetrical and chiral diamido biaryls and their supramolecular networks.
