58532-79-9Relevant academic research and scientific papers
Design, Synthesis, and Structure-Activity Relationship Study of Pyrazolones as Potent Inhibitors of Pancreatic Lipase
Zhang, Jing,Yang, Yang,Qian, Xing-Kai,Song, Pei-Fang,Zhao, Yi-Shu,Guan, Xiao-Qing,Zou, Li-Wei,Bao, Xiaoze,Wang, Hong
supporting information, p. 1600 - 1604 (2021/03/03)
Pancreatic lipase (PL), a key target for the prevention and treatment of obesity, plays crucial roles in the hydrolysis and absorption of in dietary fat. In this study, a series of pyrazolones was synthesized, and their inhibitory effects against PL were
Organocatalytic Amination of Pyrazolones with Azodicarboxylates: Scope and Limitations
Formánek, Bed?ich,?eferna, Vít,Meazza, Marta,Rios, Ramon,Patil, Mahendra,Vesely, Jan
supporting information, p. 2362 - 2366 (2021/03/16)
The organocatalytic amination of pyrazol-5-ones with azodicarboxylates (catalyzed by quinine) is reported. This asymmetric process furnishes enantiomerically enriched hydrazine adducts containing quaternary stereocenters in high yields (74–96 %) and enant
Alkynylation of heterocyclic compounds using hypervalent iodine reagent
Kamlar,Císa?ová,Vesely
, p. 2884 - 2889 (2015/04/27)
The alkynylation of various nitrogen- and/or sulphur-containing heterocyclic compounds using hypervalent iodine TMS-EBX by utilization of tertiary amines under mild conditions is described. The developed metal-free methodology furnishes the corresponding alkynylated heterocycles bearing quaternary carbon in high yields.
