58547-33-4Relevant academic research and scientific papers
Diastereoselective aldol and reformatsky reactions of α-halo carbonyl compounds and aldehydes mediated by Titanium(II) Chloride
Kagayama,Igarashi,Shiina,Mukaiyama
, p. 2579 - 2585 (2007/10/03)
Highly diastereoselective aldol reactions of α-bromo ketones with several aldehydes were successfully carried out by using a combination of titanium(II) chloride and copper or sodium iodide in dichloromethane-pivalonitrile at low temperature. Similarly, Reformatsky reactions of α-bromo thioester with aliphatic aldehydes proceeded to afford β-hydroxy thioesters in good yields under mild conditions.
ENANTIOSELECTIVE ALDOL CONDENSATIONS: THE USE OF KETONE BORON ENOLATES WITH CHIRAL LIGANDS ATTACHED TO BORON.
Paterson, Ian,Lister, M. Anne,McClure, Cynthia K.
, p. 4787 - 4790 (2007/10/02)
Aldol condensation between diethylketone and simple aldehydes using (Ipc)2BOTf/iPr2NEt in CH2Cl2 gives syn adducts in good ee (66-90percent) and with high diastereoselectivity (>=90percent).Other chiral dialkylboron triflate reagents examined give lower ees.
