585571-74-0

Upstream product

• 20913-05-7 (Benzoylmethylene)triphenylphosphorane 
• 585571-72-8 3-[(1-methyl-1H-indol-2-yl)methoxy]propane-1,2-diol 
• 768-03-6 Phenyl vinyl ketone 
• 585571-70-6 2-(allyloxymethyl)-1-methyl-1H-indole 
• 37493-34-8 methyl 1-methyl-1H-indole-2-carboxylate 
• 1202-04-6 indole-2-carboxylic acid methyl ester 
• 1485-22-9 (1-methyl-1H-indol-2-yl)-methanol 
• 1477-50-5 Indole-2-carboxylic acid 

Downstream Products

• 912756-16-2 2-(9-methyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-4-yl)-1-phenylethanone 

Relevant academic research and scientific papers

A practical synthetic route to functionalized THBCs and oxygenated analogues via intramolecular Friedel-Crafts reactions

A practical catalytic approach to the synthesis of 4-substituted 1,2,3,4-tetrahydro-β-carbolines (THBCs, 1) and 1,2,3,9-tetrahydropyrano[3, 4-b]indoles (2) via InBr3-catalyzed intramolecular Friedel-Crafts (F-C) cyclization is described. The us

New versatile route to the synthesis of tetrahydro-β-carbolines and tetrahydro-pyrano[3,4-b]indoles via an intramolecular Michael addition catalyzed by InBr3

A simple multistep synthetic strategy to 4-sub-stituted 1,2,3,4-tetrahydro-β-carboline and 1,3,4,9-tetrahydro-pyrano[3,4-b]indole derivatives starting from commercially available indole 2-carboxylic acid (5) is described. The final intramolecular Michael addition promoted by catalytic amount of InBr3 (5-10 mol %) provided the expected polycyclic compounds in excellent yields (up to 97%) both in anhydrous organic and aqueous media.