58562-46-2

Usage

General Description

2-(carbamoylmethoxy)nitrobenzene is a chemical compound with a molecular formula C8H8N2O5. It is a nitrobenzene derivative with a carbamoylmethoxy functional group attached to the benzene ring. 2-(carbamoylmethoxy)nitrobenzene is used in the synthesis of various pharmaceuticals and organic compounds due to its ability to act as a building block in organic chemistry reactions. It is also used as a starting material for the production of other important chemical compounds. Additionally, it has potential applications in the field of medicinal chemistry and drug development.

Upstream product

• 824-39-5 sodium o-nitrophenate 
• 683-57-8 bromo-acetic acid amide 
• 88-75-5 2-hydroxynitrobenzene 
• 1878-87-1 2-nitrophenoxyacetic acid 
• 20142-87-4 2-(2-nitrophenoxy)acetyl chloride 
• 7506-93-6 2-(2-nitrophenoxy)-acetic acid methyl ester 

Downstream Products

• 177202-68-5 2-(2-aminophenoxy)-acetamide 
• 1409968-67-7 C₂₄H₂₅FN₄O₃ 

Relevant academic research and scientific papers

Pyrrolidinyl phenylurea derivatives as novel CCR3 antagonists

Optimization starting with our lead compound 1 (IC50 = 4.9 nM) led to the identification of pyrrolidinyl phenylurea derivatives. Further modification toward improvement of the bioavailability provided (R)-1-(1-((6-fluoronaphthalen-2-yl)methyl)pyrrolidin-3-yl)-3-(2-(2- hydroxyethoxy)phenyl)urea 32 (IC50 = 1.7 nM), a potent and orally active CCR3 antagonist.

2-Ureido-thiazole derivatives, process for their preparation, and their use as antitumor agents

Compounds which are 2-ureido-1,3-thiazole derivatives of formula (I) wherein R is a halogen atom, a nitro group, an optionally substituted amino group or it is a group, optionally further substituted, selected from: i) straight or branched C1-C6 alkyl; ii) C3-C6 cycloalkyl; iii) aryl or arylalkyl with from 1 to 6 carbon atoms within the straight or branched alkyl chain; R1 is an optionally substituted group selected from: i) straight or branched C1-C6 alkyl; ii) 3 to 6 membered carbocycle or 5 to 7 membered heterocycle ring, iii) aryl or arylcarbonyl; iv) arylalkyl with from 1 to 6 carbon atoms within the straight or branched alkyl chain: R2 is hydrogen, a straight or branched C1-C4 alkyl or C2-C4 alkenyl or alkynyl group; or, taken together with the nitrogen atom to which they are bonded, R1 and R2 form a substituted or unsubstituted group selected from: i) an optionally benzocondensed or bridged 5 to 7 membered heterocycle; or ii) a 9 to 11 membered spiro-heterocyclic compound; or a pharmaceutically acceptable salt thereof; are useful for treating cell proliferative disorders associated with an altered cell dependent kinase activity.