58570-67-5

Basic information

• Product Name: N-(4-hydroxy-3-methoxybenzyl)hexanamide
• Synonyms: hexanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-
• CAS NO: 58570-67-5
• Molecular Formula: C₁₄H₂₁NO₃
• Molecular Weight: 251.3214
• Mol File: 58570-67-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 463.7°C at 760 mmHg
• Flash Point: 234.2°C
• Density: 1.077g/cm³
• Vapor Pressure: 3.21E-09mmHg at 25°C
• Refractive Index: 1.522
• CAS DataBase Reference: N-(4-hydroxy-3-methoxybenzyl)hexanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-hydroxy-3-methoxybenzyl)hexanamide(58570-67-5)
• EPA Substance Registry System: N-(4-hydroxy-3-methoxybenzyl)hexanamide(58570-67-5)

Safety Data

• Hazardous Substances Data: 58570-67-5(Hazardous Substances Data)

Upstream product

• 7149-10-2 vanillylamine hydrochloride 
• 142-61-0 Hexanoyl chloride 
• 1196-92-5 Vanillylamin 
• 142-62-1 hexanoic acid 

Relevant articles and documents

Vanilla amide synthesis method

The invention discloses a vanilla amide synthesis method, which comprises the following step: by taking alcohol and vanilla amide as raw materials, or aldehyde and vanilla amide as raw materials, inorganic ferric salt and inorganic indium salt as a composite catalyst and oxygen as an oxidant, carrying out one-pot reaction in an organic solvent to generate vanilla amide. The synthesis raw materials adopted by the synthesis method are wide in source, a large amount of chemical reaction waste can be avoided in the whole reaction process, and the synthesis method is clean and environmentally friendly, has the advantages of mild and controllable reaction conditions, simple operation, convenience in product separation and purification, high product yield, wide universality of reaction substrates and the like, and is a method suitable for industrial production.

Highly efficient synthesis of capsaicin analogues by condensation of vanillylamine and acyl chlorides in a biphase H2O/CHCl3 system

Highly efficient synthesis of capsaicin analogues was developed using condensation of vanillylamine with acyl chlorides in a biphase H2O/CHCl3 system under mild conditions. For C4-C18 aliphatic or aromatic acyl chlorides, the yields were up to 93-96% with high purity after a simple work-up procedure, and only 1-1.16 equiv of acyl chloride was needed in the reaction.