58611-58-8

Usage

Uses

Used in Medicinal Chemistry:
(2R,3S,4R,5R)-2-(aMinoMethyl)-5-(6-(benzylaMino)-1H-purin-9(6H)-yl)tetrahydrofuran-3,4-diol is used as a key intermediate in the synthesis of novel pharmaceutical compounds for various therapeutic applications. Its unique structure allows for the development of new drugs with improved efficacy and selectivity.
Used in Drug Development:
In the pharmaceutical industry, (2R,3S,4R,5R)-2-(aMinoMethyl)-5-(6-(benzylaMino)-1H-purin-9(6H)-yl)tetrahydrofuran-3,4-diol is used as a lead compound for the discovery of new therapeutic agents. Its potential biological activity and unique structural features make it a promising candidate for further research and development.
Used in Pharmacological Research:
(2R,3S,4R,5R)-2-(aMinoMethyl)-5-(6-(benzylaMino)-1H-purin-9(6H)-yl)tetrahydrofuran-3,4-diol is utilized as a research tool in pharmacological studies to investigate its interactions with biological targets and understand its mechanism of action. This knowledge can contribute to the advancement of drug discovery and the development of more effective treatments for various diseases.

Upstream product

• 58-61-7 adenosine 
• 21950-36-7 5'-amino-5'-deoxy-2',3'-O-isopropylideneadenosine 
• 80860-44-2 2-[[(3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]methyl]-2,3-dihydro-1H-isoindol-1,3-dione 
• 362-75-4 2',3'-isopropylidene adenosine 
• 100-52-7 benzaldehyde 

Downstream Products

• 1381762-79-3 methyl 5-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(benzyl)amino)pentanoate 
• 1381761-88-1 1-(3-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(benzyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea 
• 1381761-87-0 1-(3-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(benzyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea 
• 30765-12-9 (2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-[(benzylamino)methyl]oxolane-3,4-diol 

Relevant academic research and scientific papers

Parallel solution-phase synthesis of an adenosine antibiotic analog library

A library of eighty one adenosine antibiotic analogs was prepared under the Pilot Scale Library Program of the NIH Roadmap initiative from 5′-amino-5′-deoxy-2′,3′-O-isopropylidene-adenosine 3. Diverse aldehyde, sulfonyl chloride and carboxylic acid reactant sets were condensed to 3, in solution-phase fashion, leading after acid-mediated hydrolysis to the targeted compounds in good yields and high purity. No marked antituberculosis or anticancer activity was noted on preliminary cellular testing, but these nucleoside analogs should be useful candidates for other types of biological activity.

MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF

Disclosed are compounds, pharmaceutical compositions containing the compounds, and the uses of the compounds and compositions as modulators of histone methyltransferases, and for treating diseases influenced by modulation of histone methyltransferase activity.