5862-40-8Relevant academic research and scientific papers
POLYAMINE PRODRUGS AND POLYAMINE PRODRUG FORMULATIONS
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Paragraph 0050; 0051; 0061; 0062, (2019/10/01)
Provided herein are copolymers comprising monomers of a polyamine and a degradable linker, and further comprising a stabilizing moiety, a fluorinated moiety, a poly(ethylene glycol) (PEG) which is optionally substituted with a targeting moiety, or a combination thereof. Also provided are nanoparticles comprising copolymers as described herein, and methods of using the copolymers and nanoparticles for treating diseases or disorders, e.g., Snyder Robinson Disease or cancer.
Substrate structure-activity relationships guide rational engineering of modular polyketide synthase ketoreductases
Bailey, Constance B.,Pasman, Marjolein E.,Keatinge-Clay, Adrian T.
supporting information, p. 792 - 795 (2016/01/12)
Modular polyketide synthase ketoreductases can set two chiral centers through a single reduction. To probe the basis of stereocontrol, a structure-activity relationship study was performed with three α-methyl, β-ketothioester substrates and four ketoreductases. Since interactions with the β-ketoacyl moiety were found to be most critical, residues implicated in contacting this moiety were mutated. Two mutations were sufficient to completely reverse the stereoselectivity of the model ketoreductase EryKR1, converting it from an enzyme that generates (2S,3R)-products into one that yields (2S,3S)-products.
Phototransformation of carboxin in water. Toxicity of the pesticide and its sulfoxide to aquatic organisms
Dellagreca, Marina,Iesce, Maria Rosaria,Cermola, Flavio,Rubino, Maria,Isidori, Marina
, p. 6228 - 6232 (2007/10/03)
Sunlight exposure of aqueous suspensions of carboxin (1) causes its phototransformation to sulfoxide 2 and minor components. Similar effects are observed in the presence of humic acid or nitrate or at different pH values. Photoproducts 2-9 were isolated by Chromatographic techniques and/or identified by spectroscopic means. Carboxin 1 and its main photoproduct sulfoxide 2 were tested to evaluate acute toxicity to primary consumers typical of the aquatic environment: the rotifer Brachionus calyciflorus and two crustaceans, Daphnia magna and Thamnocephalus platyurus. Chronic tests comprised a producer, the alga Pseudokirchneriella subcapitata, and a consumer, the crustacean Ceriodaphnia dubia.
Potassium fluoride assisted selective acetylation of alcohols with acetic acid
Bosco, J. W. John,Raju, B. Rama,Saikia, Anil K.
, p. 2849 - 2855 (2007/10/03)
Potassium fluoride promotes the acetylation of primary and secondary alcohols with acetic acid in excellent yield. Phenols are not affected under this reaction conditions. The groups like double bond, chloro, methoxy, benzyloxy, thiol, and nitro remain unaffected.
Palladium(II) chloride catalyzed selective acetylation of alcohols with vinyl acetate
Bosco,Saikia, Anil K.
, p. 1116 - 1117 (2007/10/03)
PdCl2 can catalyze the acetylation of primary and secondary alcohols with vinyl acetate. The reaction is selective and mild with high yields. Tertiary alcohols, phenols and amines are unaffected under these reaction conditions.
Yttria-zirconia based Lewis acid: An efficient and chemoselective catalyst for acylation reactions
Kumar,Pandey,Bodas,Dongare
, p. 206 - 209 (2007/10/03)
Yttria-zirconia based strong Lewis acid efficiently catalyzes acylation of alcohols, amines and thiols under environmentally safe, heterogeneous reaction conditions with high selectivity and in excellent yields.
Montmorillonite clay catalysis. Part 10. K-10 and KSF-catalysed acylation of alcohols, phenols, thiols and amines: Scope and limitation
Li, Tong-Shuang,Li, Ai-Xiao
, p. 1913 - 1917 (2007/10/03)
Montmorillonite K-10 and KSF are highly efficient catalysts for the acetylation of a variety of alcohols, thiols, phenols and amines with acetic anhydride. Amino groups can be selectively acetylated in the presence of hydroxy groups, while the hydroxy groups can be preferentially acetylated in the presence of thiol groups. No selectivity is observed between primary and secondary hydroxy groups in the presence of K-10 and KSF. The catalysts are found not to be efficient for acetylation of tertiary alcohols. This method is simple and convenient with minimum environmental impact. The catalysts are also effective for the acylation of alcohols, thiols, phenols and amines with acetyl chloride and benzoyl chloride. Cyclic anhydrides such as succinic anhydride, maleic anhydride and phthalic anhydride and p-toluene sulfonyl chloride show less reactivity than acetic anhydride and acyl chlorides.
Montmorillonite K-10 and KSF as remarkable acetylation catalysts
Li, Ai-Xiao,Li, Tong-Shuang,Ding, Tian-Hui
, p. 1389 - 1390 (2007/10/03)
Montmorillonite K-10 and KSF catalyse the acetylation of alcohols, thiols, phenols and amines with acetic anhydride in excellent yield.
