58632-85-2

Basic information

• Product Name: Ethanone, 1-(2-butylphenyl)-
• CAS NO: 58632-85-2
• Molecular Formula: C12H16O
• Molecular Weight: 176.258
• Mol File: 58632-85-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-(2-butylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(2-butylphenyl)-(58632-85-2)
• EPA Substance Registry System: Ethanone, 1-(2-butylphenyl)-(58632-85-2)

Safety Data

• Hazardous Substances Data: 58632-85-2(Hazardous Substances Data)

Usage

General Description

1-(2-butylphenyl)ethanone is a chemical compound with the molecular formula C12H16O. It is also known as benzyl ethyl ketone or phenyl butyl ketone. This chemical is commonly used in the production of fragrances and flavors due to its sweet, fruity odor. It is a colorless liquid with a pleasant smell, making it an ideal ingredient in perfumes, cosmetics, and food products. Additionally, 1-(2-butylphenyl)ethanone has been found to exhibit antioxidant and anti-inflammatory properties, making it a potentially useful ingredient in the pharmaceutical industry for developing drugs to treat conditions such as inflammation and oxidative stress.

Upstream product

• 4426-47-5 butylboronic acid 
• 2142-69-0 2-bromophenyl methyl ketone 
• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 693-04-9 butyl magnesium bromide 
• 109-72-8 n-butyllithium 
• 542-69-8 1-iodo-butane 
• 129849-05-4 trifluoromethanesulfonic acid 2-acetylphenyl ester 
• 103562-91-0 2-Butyl-N-(2-dimethylamino-ethyl)-N-methyl-benzamide 
• 74-88-4 methyl iodide 
• 2743-00-2 (E)-4-methoxy-N-(1-phenylethylidene)benzenamine 
• 78-76-2 s-butyl bromide 

Relevant articles and documents

Scalable Negishi Coupling between Organozinc Compounds and (Hetero)Aryl Bromides under Aerobic Conditions when using Bulk Water or Deep Eutectic Solvents with no Additional Ligands

Pd-catalyzed Negishi cross-coupling reactions between organozinc compounds and (hetero)aryl bromides have been reported when using bulk water as the reaction medium in the presence of NaCl or the biodegradable choline chloride/urea eutectic mixture. Both C(sp3)-C(sp2) and C(sp2)-C(sp2) couplings have been found to proceed smoothly, with high chemoselectivity, under mild conditions (room temperature or 60 °C) in air, and in competition with protonolysis. Additional benefits include very short reaction times (20 s), good to excellent yields (up to 98 %), wide substrate scope, and the tolerance of a variety of functional groups. The proposed novel protocol is scalable, and the practicability of the method is further highlighted by an easy recycling of both the catalyst and the eutectic mixture or water.

Cobalt-catalyzed ortho alkylation of aromatic imines with primary and secondary alkyl halides

We report here cobalt-N-heterocyclic carbene catalytic systems for the ortho alkylation of aromatic imines with alkyl chlorides and bromides, which allows the introduction of a variety of primary and secondary alkyl groups at room temperature. The stereochemical outcomes of the reaction of secondary alkyl halides suggest that the present reaction involves single-electron transfer from a cobalt species to the alkyl halide to generate the corresponding alkyl radical. A cycloalkylated product obtained by this method can be transformed into unique spirocycles through manipulation of the directing and cycloalkyl groups.

Tetraphosphine/palladium catalysed Suzuki cross-coupling reactions of aryl halides with alkylboronic acids

Through the use of [PdCl(C3H5)]2/cis,cis, cis-1,2,3,4-tetrakis(diphenylphosphinomethyl)cyclopentane as a catalyst, a range of aryl bromides and chlorides undergoes Suzuki cross-coupling with alkylboronic acids in good yields. Several alkyl substituents such as ethyl, n-butyl, n-octyl, isobutyl or 2,2-dimethylpropyl on the alkylboronic acids have been successfully used. The functional group tolerance on the aryl halide is remarkable; substituents such as fluoro, methyl, methoxy, acetyl, formyl, benzoyl, nitro or nitrile are tolerated. Furthermore, this catalyst can be used at low loading, even for reactions of sterically hindered aryl bromides.