586414-93-9

Basic information

• Product Name: rel-5-Chloro-N-[2-[4-[[[[[(1R,2R)-2-hydroxycyclohexyl]aMino]carbonyl]aMino]sulfonyl]phenyl]ethyl]-2-MethoxybenzaMide
• Synonyms: rac trans-2-Hydroxy Glyburide;rel-5-Chloro-N-[2-[4-[[[[[(1R,2R)-2-hydroxycyclohexyl]aMino]carbonyl]aMino]sulfonyl]phenyl]ethyl]-2-MethoxybenzaMide
• CAS NO: 586414-93-9
• Molecular Formula: C23H28ClN3O6S
• Molecular Weight: 510.00292
• Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 586414-93-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: rel-5-Chloro-N-[2-[4-[[[[[(1R,2R)-2-hydroxycyclohexyl]aMino]carbonyl]aMino]sulfonyl]phenyl]ethyl]-2-MethoxybenzaMide(CAS DataBase Reference)
• NIST Chemistry Reference: rel-5-Chloro-N-[2-[4-[[[[[(1R,2R)-2-hydroxycyclohexyl]aMino]carbonyl]aMino]sulfonyl]phenyl]ethyl]-2-MethoxybenzaMide(586414-93-9)
• EPA Substance Registry System: rel-5-Chloro-N-[2-[4-[[[[[(1R,2R)-2-hydroxycyclohexyl]aMino]carbonyl]aMino]sulfonyl]phenyl]ethyl]-2-MethoxybenzaMide(586414-93-9)

Safety Data

• Hazardous Substances Data: 586414-93-9(Hazardous Substances Data)

Usage

Uses

rac trans-2-Hydroxy Glyburide is a metabolite of Glyburide which is used as an antidiabetic (MIV-metabolite).

Upstream product

• 16673-34-0 5-chloro-2-methoxy-N-(4-sulfamoylphenethyl)benzamide 
• 14511-59-2 Ethyl 4-<2-(5-chloro-2-methoxybenzamido)ethyl>benzenesulfonamidecarbamate 
• 931-16-8 (+/-)-trans-2-aminocyclohexanol 

Relevant articles and documents

Hydroxyl-Substituted sulfonylureas as potent inhibitors of specific [3H]Glyburide binding to rat brain synaptosomes

We are seeking to discover potent CNS-active sulfonylureas with structural features that allow for the formation of several types of prodrugs. We report herein the syntheses of compounds comprising an initial series of hydroxyl-substituted analogues of the potent ATP-sensitive potassium channel blockers glyburide (glibenclamide) and gliquidone. Somewhat unexpectedly, several of the compounds were found to be comparably potent to glyburide as inhibitors of specific [3H]glyburide binding in rat brain preparations.