5866-40-0

Upstream product

• 28895-02-5 3,4-dimethyl-2,5-hexanedione 
• 526-79-4 2,3-dimethyl-4-oxo-valeric acid 
• 27697-13-8 2-methyl-3-methylenesuccinic acid 
• 123-91-1 1,4-dioxane 
• 608-40-2 meso 2,3-dimethylsuccinic acid 
• 67-56-1 methanol 
• 2985-33-3 monoethyl methylmalonate 
• 766-39-2 2,3-Dimethylmaleic anhydride 
• 21788-49-8 (E)-2,3-dimethyl-2-butenedioic acid 
• 108-98-5 thiophenol 
• 598-72-1 2-Bromopropionic acid 
• 142-45-0 Acetylenedicarboxylic acid 
• 58342-54-4 (R^*,R^*)-dimethyl 2,3-dimethylsuccinate 
• 95864-67-8 trans-2,2-dichloro-3,4-dimethylcyclobutanone 

Downstream Products

• 608-40-2 meso 2,3-dimethylsuccinic acid 
• 57716-80-0 rac-2,3-dimethylbutane-1,4-diol 
• 74939-90-5 (2R,3S)-2,3-dimethylbutane-1,4-diol 
• 13122-66-2 (+/-)-erythro-4-oxo-2.3-dimethyl-4-phenyl-butyric acid 
• 766-39-2 2,3-Dimethylmaleic anhydride 
• 57340-48-4 racem.-2,3-dimethyl-1,4-bis-(toluene-4-sulfonyloxy)-butane 

Relevant academic research and scientific papers

Double Asymmetric Hydrogenation of Conjugated Dienes Catalysed by Ruthenium-binap Complexes

Buta-1,3-diene-2,3-dicarboxylic acid is smoothly hydrogenated in the presence of ruthenium-(R)-binap complexes as a catalyst via two consecutive 1,2-hydrogen additions, giving rise to (S,S)-2,3-dimethylsuccinic acid with 98percent diastereoisomeric excess and 96percent enantiomeric excess.

Stereoselective homogeneous hydrogenation. The basis of preferential anti-isomer formation in acyclic systems

Directed homogeneous hydrogenation of olefins derived from methyl acrylate proceeds with high selectivity.The reactant must possess a polar substituent at a chiral centre situated in the α'-position; this may be -OH, CO2R or NHCOR.The catalyst should be a cationic chelating rhodium biphosphine complex.In all cases high anti-stereoselectivity is observed in the reduced product, and this can be rationalised by a simple and general model.With an optically active catalyst, efficient kinetic resolution occurs, providing a means of access to optically active acrylates.Experimental details of typical hydrogenation reactions are provided.

HIGHLY DIASTEREOSELECTIVE TANDEM ALKYLATION OF ACYCLIC α,β-UNSATURATED ESTERS BASED ON THE NOVEL USE OF DITHIOACETAL UNIT

Highly diastereoselective tandem alkylation process of acyclic α,β-unsaturated esters was developed based on the novel use of dithioacetal as a stereocontrolling unit.

OXIDATIVE COUPLING REACTIONS UNDER PTC CONDITIONS

Succinic acid derivatives have been prepared from cyanohalides under PTC conditions in good yields.

DIMETALATED TERTIARY SUCCINAMIDES. ALKYLATION AND ANNELATION REACTIONS

The reactions of dimetalated succinamides 1 with a variety of electrophiles give 2,3-disubstituted adducts (2) with high diasterioselectivity and annelated products (6-9).