2985-33-3

Basic information

• Product Name: 3-ethoxy-2-Methyl-3-oxopropanoic acid
• Synonyms: 3-ethoxy-2-Methyl-3-oxopropanoic acid;Propanedioic acid, 2-Methyl-, 1-ethyl ester;2-Methyl-malonic acid monoethyl ester
• CAS NO: 2985-33-3
• Molecular Formula: C₆H₁₀O₄
• Molecular Weight: 146.1412
• Mol File: 2985-33-3.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 242.45 °C at 760 mmHg
• Flash Point: 98.414 °C
• Appearance: /
• Density: 1.159 g/cm³
• Vapor Pressure: 0.0112mmHg at 25°C
• Refractive Index: 1.438
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-ethoxy-2-Methyl-3-oxopropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ethoxy-2-Methyl-3-oxopropanoic acid(2985-33-3)
• EPA Substance Registry System: 3-ethoxy-2-Methyl-3-oxopropanoic acid(2985-33-3)

Safety Data

• Hazardous Substances Data: 2985-33-3(Hazardous Substances Data)

Usage

Uses

Ethyl 2-Carboxypropionate is a useful synthetic compound.

InChI:InChI=1/C6H10O4/c1-3-10-6(9)4(2)5(7)8/h4H,3H2,1-2H3,(H,7,8)

Upstream product

• 141-52-6 sodium ethanolate 
• 609-08-5 Diethyl methylmalonate 
• 105-53-3 diethyl malonate 
• 64-17-5 ethanol 
• 1447797-55-8 diethyl 2-(3,5-di-tert-butylbenzyl)-2-methylmalonate 
• 1447797-53-6 diethyl 2-methyl-2-(4-(trifluoromethyl)benzyl)malonate 
• 292638-85-8 acrylic acid methyl ester 
• 103362-70-5 potassium ethyl methylmalonate 
• 34780-08-0 2-(phenylthio)cyclopent-2-en-1-one 
• 50405-41-9 ethyl hydrogen methylmalonate magnesium enolate 
• 541-41-3 chloroformic acid ethyl ester 
• 802294-64-0 propionic acid 
• 105-37-3 Ethyl propionate 
• 2009-97-4 ethyl 2-diazo-3-oxobutanoate 

Downstream Products

• 609-14-3 2-acetylpropanoic acid ethyl ester 
• 97-63-2 methyl methacrylate 
• 1575-08-2 2-methyl-3-(4-methoxyphenyl)-3-oxopropionic acid ethyl ester 
• 1027196-76-4 C₂₃H₄₂N₄O₇ 
• 102-53-4 bis-(diethylamino)methane 
• 105-37-3 Ethyl propionate 
• 140-88-5 ethyl acrylate 
• 42710-28-1 ethyl 3-amino-2-methyl-3-oxopropanoate 
• 847926-36-7 2-Methyl-N-(2,2,2-trifluoro-ethyl)-malonamic acid ethyl ester 
• 138032-47-0 ethyl 2-[2-methylamino-4-(2-chloro-4-trifluoromethyl-6-fluorophenoxy)phenylcarbamoyl] propionate 
• 116023-06-4 benzyl 4-ethoxycarbonyl-3-oxopentanoate 

Relevant articles and documents

Aspidosperma Alkaloids via Cyclization of Secodine Intermediate: Synthesis of (+/-)-3-Oxovincadifformine Ethyl Ester

(+/-)-3-oxovincadifformine ethyl ester 14 has been synthesized through an intramolecular cycloaddition of the 3-oxosecodine 13 first prepared in turn from the enamide 10 by dehydrogenation with benzeneseleninic anhydride.An insight into the conversion of 10 into 13 was gained, resulting in the suggestion of a plausible mechanistic pathway.

Hydrogen-Bonding Assisted Catalytic Kinetic Resolution of Acyclic β-Hydroxy Amides

Enantioenriched acyclic α-substituted β-hydroxy amides are valuable compounds in chemical, material and medicinal sciences, but their enantioselective synthesis remains challenging. A catalytic kinetic resolution (KR) of such amides with selectivity factor(s) up to >200 is developed via enantioselective acylation of primary alcohol with N-heterocyclic carbene. An enhanced selectivity for the catalytic KR process is realized using cyclic tertiary amine as base additive. Diastereomeric transition state models for the process are proposed to rationalize the origin of enantioselectivity.

Enantioselective α-Amination of Acyclic 1,3-Dicarbonyls Catalyzed by N-Heterocyclic Carbene

Herein, we describe a method for the catalytic enantioselective α-amination of α-substituted acyclic 1,3-ketoamides and 1,3-amidoesters that affords the products possessing N-substituted quaternary stereocenters with a chiral N-heterocyclic carbene (NHC). The reaction is based on the utilization of an intrinsic Br?nsted base characteristic of NHC that enables the catalytic formation of a chiral ion pair comprising the enolate and the azolium ion. A series of challenging open-chain α-substituted 1,3-dicarbonyls are aminated via this method with ee's of ≤99%.