58662-08-1

Upstream product

• 62673-31-8 benzyl(bromo)zinc 
• 122-00-9 para-methylacetophenone 
• 637-50-3 1-phenylpropene 
• 22927-00-0 2-(4-methylphenyl)-1-phenyl-2-propanol 
• 1427318-48-6 C₁₇H₁₈S 
• 676-58-4 methylmagnesium chloride 
• 1427318-05-5 (E)-(1-chloro-2-phenylvinyl)(ethyl)sulfane 
• 14476-62-1 1-Ethylthio-2-phenyl-acetylen 
• 624-31-7 4-tolyl iodide 
• 1080-32-6 O,O-diethyl benzylphosphonate 
• 100-44-7 benzyl chloride 
• 91176-32-8 1-methyl-4-(3-phenylprop-1-en-2-yl)benzene 
• 103-80-0 phenylacetyl chloride 
• 106-38-7 para-bromotoluene 

Downstream Products

• 83832-29-5 1-((1R,2S)-2-Bromo-1-methoxy-1-methyl-2-phenyl-ethyl)-4-methyl-benzene 
• 83832-13-7 1-((1R,2R)-2-Bromo-1-methoxy-1-methyl-2-phenyl-ethyl)-4-methyl-benzene 

Relevant academic research and scientific papers

A new insight into the push-pull effect of substituents via the stilbene-like model compounds

In this paper, authors report on 1-pyridyl-2-arylethenes, 1-furyl-2-arylethylenes, 1,2-diphenylpropylenes and substituted cinnamyl anilines as stilbene-like model compounds to investigate the factors dominating the push-pull effect of substituents via usi

Cobalt(II)-Catalyzed Stereoselective Olefin Isomerization: Facile Access to Acyclic Trisubstituted Alkenes

Stereoselective synthesis of trisubstituted alkenes is a long-standing challenge in organic chemistry, due to the small energy differences between E and Z isomers of trisubstituted alkenes (compared with 1,2-disubstituted alkenes). Transition metal-catalyzed isomerization of 1,1-disubstituted alkenes can serve as an alternative approach to trisubstituted alkenes, but it remains underdeveloped owing to issues relating to reaction efficiency and stereoselectivity. Here we show that a novel cobalt catalyst can overcome these challenges to provide an efficient and stereoselective access to a broad range of trisubstituted alkenes. This protocol is compatible with both mono- and dienes and exhibits a good functional group tolerance and scalability. Moreover, it has proven to be a useful tool to construct organic luminophores and a deuterated trisubstituted alkene. A preliminary study of the mechanism suggests that a cobalt-hydride pathway is involved in the reaction. The high stereoselectivity of the reaction is attributed to both a π-πstacking effect and the steric hindrance between substrate and catalyst.

Supported Au Nanoparticles-Catalyzed Regioselective Dehydrogenative Disilylation of Allenes by Dihydrosilane

Supported Au nanoparticles on TiO2 catalyze the unprecedented dehydrogenative disilylation of monosubstituted and 1,1-disubstituted allenes by Et2SiH2 exclusively on the terminal double bond in a stereoselective manner. Tr

Dipalladium(I) complexes of ortho- and para-functionalized 1,3-bis(aryl)triazenide ligands: Synthesis, structure and catalytic activity

The synthesis and characterization of a series dipalladium(I) complexes of formulae [Pd{1-[2′-(methoxycarbonyl)phenyl]-3-[4′-X-phenyl]triazenide}]2 [X = F (4), Cl (5), Br (6)] are reported. The crystal structure of complex 4 was determined by X-ray diffraction studies. The previously reported dipalladium(I) 1–3 as well as the new complexes 4–6 were used as catalysts in the Heck and Suzuki couplings of different p-substituted bromobenzenes.

Chloride-Bridged Dinuclear Rhodium(III) Complexes Bearing Chiral Diphosphine Ligands: Catalyst Precursors for Asymmetric Hydrogenation of Simple Olefins

Efficient rhodium(III) catalysts were developed for asymmetric hydrogenation of simple olefins. A new series of chloride-bridged dinuclear rhodium(III) complexes 1 were synthesized from the rhodium(I) precursor [RhCl(cod)]2, chiral diphosphine ligands, and hydrochloric acid. Complexes from the series acted as efficient catalysts for asymmetric hydrogenation of (E)-prop-1-ene-1,2-diyldibenzene and its derivatives without any directing groups, in sharp contrast to widely used rhodium(I) catalytic systems that require a directing group for high enantioselectivity. The catalytic system was applied to asymmetric hydrogenation of allylic alcohols, alkenylboranes, and unsaturated cyclic sulfones. Control experiments support the superiority of dinuclear rhodium(III) complexes 1 over typical rhodium(I) catalytic systems.

A regio- and stereoselective entry to (Z)-β-halo alkenyl sulfides and their applications to access stereodefined trisubstituted alkenes

A mild and efficient preparation of (Z)-β-halo alkenyl sulfides via the K2CO3-promoted hydrothiolation of haloalkynes has been realized, producing (Z)-β-bromo and (Z)-β-chloro vinylic sulfides in high yields with excellent regio- and

An operationally simple approach to (E)-α-halo vinyl sulfides and their applications for accessing stereodefined trisubstituted alkenes

An operationally simple and practical protocol for the synthesis of (E)-α-halo vinyl sulfides has been achieved via a highly regio- and stereoselective hydrohalogenation of alkynyl thioethers using lithium halides in HOAc or propionic acid at room temperature. It permits the formation of (E)-α-chloro and (E)-α-bromo vinyl sulfides in satisfactory yields with good to excellent stereoselectivities. Moreover, this work results in a new method for the assembly of stereodefined (E)- or (Z)-trisubstituted alkenes featuring the first coupling of the C-X bond of (E)-α-halo vinyl sulfides followed by a subsequent Ni-catalyzed coupling of the C-S bond with Grignard reagents. The Royal Society of Chemistry 2013.

Iron-catalysed tandem cross-dehydrogenative coupling (CDC) of terminal allylic C(sp3) to C(sp2) of styrene and benzoannulation in the synthesis of polysubstituted naphthalenes

A novel iron-catalysed tandem cross-dehydrogenative coupling and benzoannulation process was developed for the synthesis of biologically and synthetically important polysubstituted naphthalene derivatives from simple 1,2-aryl-propenes and styrenes in moderate to good yields. The Royal Society of Chemistry 2012.

Arylation of styrenes with aryliron complexes [CpFe(CO)2Ar]

Treatment of aryliron complexes [CpFe(CO)2Ar] with styrenes in boiling xylene affords the corresponding stilbenes. The aryliron complexes, which become active upon heating, serve as arylating agents in the reaction.

Lewis acid promoted carbon - Carbon double-bond formation via organozinc reagents and carbonyl compounds

(Chemical Equation Presented) Using cheap and readily available AlCl3 as Lewis acid, functionalized aldehydes react with organozinc reagents to give (E)-alkenes stereoselectively in high yields. 2009 American Chemical Society.