58668-52-3Relevant articles and documents
Design and synthesis of conformationally constraint Dyrk1A inhibitors by creating an intramolecular H-bond involving a benzothiazole core
Salah, Mohamed,Abdel-Halim, Mohammad,Engel, Matthias
, p. 1045 - 1053 (2018/06/27)
We present the development of conformationally pre-organised Dyrk1A inhibitors based on the hydroxybenzothiazole urea scaffold. The modifications introduced to the discovered hit (AHS-211) proved the crucial role of the urea linker to preserve the bioacti