50440-82-9

Basic information

• Product Name: 2-AMINO-6-METHYL-4(3H)-QUINAZOLONE
• Synonyms: 2-AMINO-6-METHYL-4(3H)-QUINAZOLONE;2-AMINO-6-METHYLQUINAZOLIN-4(3H)-ONE;2-Amino-6-methyl-4-quinazolone;4(3H)-Quinazolinone, 2-aMino-6-Methyl-;2-AMino-6-Methyl-3H-quinazolin-4-one;2-Amino-6-methyl-4(3H)-quinazolinone
• CAS NO: 50440-82-9
• Molecular Formula: C₉H₉N₃O
• Molecular Weight: 175.19
• Mol File: 50440-82-9.mol
• Article Data: 8

Chemical Properties

• Melting Point: >300°C
• Boiling Point: 386.5 °C at 760 mmHg
• Flash Point: 187.5 °C
• Appearance: /
• Density: 1.42 g/cm³
• Vapor Pressure: 3.54E-06mmHg at 25°C
• Refractive Index: 1.701
• Storage Temp.: 2-8°C
• Water Solubility: Slightly soluble in water.
• BRN: 609421
• CAS DataBase Reference: 2-AMINO-6-METHYL-4(3H)-QUINAZOLONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-6-METHYL-4(3H)-QUINAZOLONE(50440-82-9)
• EPA Substance Registry System: 2-AMINO-6-METHYL-4(3H)-QUINAZOLONE(50440-82-9)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36
• Hazardous Substances Data: 50440-82-9(Hazardous Substances Data)

Usage

Uses

It is employed as a intermediate for pharmaceutical.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 26, p. 1501, 1989 DOI: 10.1002/jhet.5570260548

InChI:InChI=1/C9H9N3O/c1-5-2-3-7-6(4-5)8(13)12-9(10)11-7/h2-4H,1H3,(H3,10,11,12,13)

Upstream product

• 18595-16-9 2-amino-5-methylbenzoic acid methyl ester 
• 29671-92-9 chloroformamidine hydrochloride 
• 2941-78-8 2-Amino-5-methylbenzoic acid 
• 420-04-2 CYANAMID 
• 29289-13-2 2-iodo-4-methylaniline 
• 58677-05-7 ethyl 2-amino-5-methylbenzoate 

Downstream Products

• 127117-52-6 2-amino-3,4-dihydro-3,6-dimethyl-4-oxoquinazoline 
• 131066-87-0 N-<4-prop-2-ynylamino>benzoyl>-L-glutamic acid 
• 131066-84-7 diethyl N-<4-methyl>prop-2-ynylamino>benzoyl>-L-glutamate 
• 131066-81-4 diethyl N-<4-methyl>prop-2-ynylamino>benzoyl>-L-glutamate 
• 101248-32-2 N¹⁰-propargyl-5,8-dideazapteroic acid 
• 58677-08-0 2-amino-6-(bromomethyl)-4-hydroxyquinazoline 

Relevant articles and documents

2-amino-4-oxo-quinazoline dithioformate derivative and pharmaceutical composition and application thereof

The invention discloses a 2-amino-4-oxo-quinazoline dithioformate derivative and a pharmaceutical composition and application thereof. The 2-amino-4-oxo-quinazoline dithioformate derivative is a compound shown as a formula A in the specification. The derivative disclosed by the invention has a broad-spectrum anti-tumor effect, and particularly has inhibitory activity on paclitaxel drug-resistant tumors.

QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES

This invention relates to quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy of disorders in which the modulation of toll-like-receptors is involved.

2-Pivalamido-3H-pyrimidin-4-one derivatives: Convenient pivalamide hydrolysis using Fe(NO3)3 in MeOH

A simple methodology for pivalamide (trimethylacetamide, pivaloylamino) hydrolysis has been discovered using Fe(NO3)3 in MeOH at room temperature. The pivalamido group of 2-pivalamido-3H-pyrimidin-4-ones or fused 2-pivalamido-3H-pyrimidin-4-ones such as 2-pivalamido-3H-quinazolin-4-ones and 2-pivalamido-3H-pteridines have been hydrolysed under these conditions to afford the corresponding amine.