58708-60-4Relevant academic research and scientific papers
Cyclic Urea and Thiourea Derivatives as Inducers of Murine Erythroleukemia Differentiation
Li, Chau-der,Mella, Sharon L.,Sartorelli, Alan C.
, p. 1089 - 1092 (2007/10/02)
A series of derivatives of tetramethylurea, a known inducer of the differentiation of Friend erythroleukemia cells, has been synthesized and tested for its capacity to induce erythroid maturation, as measured by the synthesis of hemoglobin.Cyclic urea and thiourea derivatives consisting of five-, six-, and seven-membered ring systems containing N-alkyl substituents were prepared.Most of these agents were relatively effective inducers of differentiation, with N-alkyl substitution appearing to be essential for maximum response.The most potent agents developed wereN,N'-dimethyl cyclic ureas.Exposure to concentrations of 2 to 4 mM of these derivatives resulted in more than 90percent of the cell population achieving a differentiated state.Under these conditions, the parent compound, tetramethylurea, was slightly less efficacious, causing differentiation of only 68percent of the population at its maximum effective level of 4 mM.
Synthesis and radioprotective effects of disodium alkanebisdithiocarbamates, ω aminoalkyldithiocarbamic acids and their N,N dimethyl derivatives
Barnes,Fatome,Esslemont,et al.
, p. 619 - 622 (2007/10/04)
The 12 compounds studied containing the dithiocarbamate group, 5 of which are new, showed remarkably low acute toxicity in mice, with LD50 values generally higher than 1,000 mg/kg by the intraperitoneal route. Most noteworthy was 2 aminoethyldithiocarbamic acid, which protected 100% of mice against an LD99 of whole body γ-radiation in dose of 750 mg/kg, while the LD50 exceeds 1,500 mg/kg: certain higher homologues and N-methylated derivatives were also radioprotective and the series may merit further study.
