52252-58-1Relevant academic research and scientific papers
All-natural carbon source raspberry ketone preparation method
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, (2019/02/04)
The invention discloses an all-natural carbon source raspberry ketone preparation method, which comprises: carrying out a demethylation reaction on naturally-derived p-anisaldehyde as a raw material to prepare p-hydroxybenzaldehyde, carrying out a Knoevenagel condensation reaction on the p-hydroxybenzaldehyde and ethyl acetoacetate derived from biomass to obtain ethyl (E/Z)-2-acetyl-3-(4-hydroxyphenyl)acrylate, and carrying out hydrogenation, hydrolysis and decarboxylation to prepare the raspberry ketone. According to the present invention, the method can achieve the preparation of the all-natural carbon source raspberry ketone, and has advantages of simple route, easy operation, environmental friendliness, high yield and the like.
Design, synthesis and computational validation of novel benzimidazole/indole-based PPARα and PPAR? partial agonists
Verma, Raman K.,Ghosh, Prithwish,Kumar, Vijay,Wadhwa, Lalit K.
, p. 1555 - 1571 (2014/04/03)
The design and synthesis of benzimidazolyl and indolyl linked α-alkoxy phenylpropanoic acid derivatives and the β-keto ester analogues in an effort to develop novel peroxisome proliferator activated receptors ligands expected to exhibit PPARα and PPAR? pa
Palladium-catalyzed dehydrogenative β′-arylation of β-keto esters under aerobic conditions: Interplay of metal and Bronsted acids
Yip, Kai-Tai,Nimje, Roshan Y.,Leskinen, Mikko V.,Pihko, Petri M.
supporting information, p. 12590 - 12594 (2012/11/13)
The Bronsted aids: The first dehydrogenative arylation of β-keto esters with arenes under ambient aerobic conditions is described (see scheme). Under a PdII/Bronsted acid co-catalytic system, regioselective arylations with alkoxylated arenes an
Efficient synthetic method of Psammaplin A
Hong, Suckchang,Lee, Myungmo,Jung, Myunggi,Park, Yohan,Kim, Mi-Hyun,Park, Hyeung-Geun
, p. 4209 - 4211 (2012/08/28)
A new concise and efficient synthetic method of Psammaplin A was developed. Psammaplin A was obtained with 50% overall yield in nine steps from p-hydroxybenzaldehyde and ethyl acetoacetate via Knoevenagel condensation and direct nitrosation as key steps.
Beta-ketoester compounds
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Page column 12, (2010/11/30)
The beta-ketoesters of formula I are useful as precursors for organoleptic compounds, especially for flavors, fragrances and masking agents and antimicrobial compounds.
Beta-ketoester compounds
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, (2008/06/13)
The beta-ketoesters of formula I are useful as precursors for organoleptic compounds, especially for flavors, fragrances and masking agents and antimicrobial compounds.
Quinone methide from 4-hydroxybenzyl alcohol diacetate: (P-acetoxy)benzylation of β-dicarbonyls
Sanner, Mark A.,Stansberry, Mary,Weigelt, Carolyn,Michne, William F.
, p. 5287 - 5290 (2007/10/02)
Diacetate 1c is a readily available quinone methide equivalent when treated with Cs2CO3 for C-(p)-acetoxy)benzylation of β-dicarbonyls in 51-89 % yield.
Simple Synthesis of 4-(Heteroarylmethyl)phenols and Their Acylation
Kuebel, Boerries
, p. 1392 - 1401 (2007/10/02)
Condensation of 4-hydroxybenzaldehyde (1) with ethyl acetoacetate (2a) or acetylacetone (2b) gives 3a and 3b, respectively, which on hydrogenation afford the 2-(4-hydroxybenzyl)-1,3-dicarbonyl compounds 4a and 4b, respectively.These react with hydrazines
