5873-00-7

Usage

Uses

Used in Pharmaceutical Industry:
3-Aminoquinoline-2(1H)-one is used as a precursor in the synthesis of bioactive compounds for its potential pharmacological properties. It serves as a key building block in the development of new drugs due to its versatile chemical structure and the possibility of forming various derivatives with therapeutic potential.
Used in Anticancer Applications:
3-Aminoquinoline-2(1H)-one is used as an anticancer agent for its potential to inhibit the growth of cancer cells. It has been studied for its ability to interfere with the proliferation and survival of malignant cells, making it a promising candidate for the development of new cancer therapies.
Used in Anti-inflammatory Applications:
3-Aminoquinoline-2(1H)-one is used as an anti-inflammatory agent for its potential to reduce inflammation and alleviate symptoms associated with inflammatory conditions. Its pharmacological properties may contribute to the modulation of inflammatory responses and the management of related disorders.
Used in Malaria Treatment:
3-Aminoquinoline-2(1H)-one is used in the treatment of malaria due to its ability to inhibit the growth of Plasmodium falciparum, the parasite responsible for the disease. Its potential role in malaria treatment is being investigated as an alternative or adjunct to existing antimalarial drugs.
Used in Organic Synthesis:
3-Aminoquinoline-2(1H)-one is used as a reagent in organic synthesis for the preparation of various chemical compounds. Its unique structure allows for a wide range of chemical reactions, making it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.

Upstream product

• 16551-96-5 3-Amino-1-hydroxy-1H-chinolin-2-on 
• 529-23-7 o-aminobenzaldehyde 
• 939-16-2 3-bromoquinolin-2-one 
• 5344-90-1 2-Aminobenzyl alcohol 
• 552-89-6 2-nitro-benzaldehyde 
• 6635-81-0 3-benzoylamino-1,2-dihydro-quinoline-2-one 
• 103029-75-0 3-nitroquinolin-2(1H)-one 
• 98293-45-9 cis-2-methyl-4-(o-nitrobenzylidene)oxazol-5-one 
• 833-62-5 N-(2-hydroxyquinolin-3-yl)acetamide 
• 335649-85-9 3-iodoquinolin-2-ol 

Downstream Products

• 116632-54-3 2-chloro-3-aminoquinoline 
• 872322-72-0 tert-butyl {(1R)-1-(2-fluorobenzyl)-3-oxo-3-[(2-oxo-1,2-dihydroquinolin-3-yl)amino]propyl}carbamate 

Relevant academic research and scientific papers

An improved method for the synthesis of 3-amino-1H-quinolin-2-one

An efficient method for the synthesis of 3-amino-1H-quinolin-2-one is described. Condensation of o-nitrobenzaldehyde with hippuric acid gave 4-(2-nitrobenzylidene)-2-phenyloxazol-5-one. This compound was reduced to give 4-(2-aminobenzylidene)-2-phenyloxaz

An expeditious copper-catalyzed access to 3-aminoquinolinones, 3-aminocoumarins and anilines using sodium azide

An efficient copper-catalyzedin in situ C-(sp2)-NH2 bond formation to provide a range of 3-aminoquinolin-2(1H)-ones and 3-aminocoumarins from 3-bromoquinolinones and 3-bromocoumarins, respectively, has been achieved. The reaction conditions involve the use of copper powder as the catalyst, eco-friendly ethanol as the solvent in the pres ence of pipecolinic acid as the ligand and ascorbic acid as the additive. The efficiency of this practical method was demonstrated in the synthesis of various anilines.

Synthesis of 4-(2-chloroethyl)-2,3-dihydro[1,4]oxazino[2,3-b]quinoline and 4-(2-chloroethyl)-2,3-dihydropyrido[2,3-b][1,4]oxazine

The title compounds were synthesized from 3-[bis(2- hydroxyethyl)amino]quinolin-2(1H)-one 11a and 3-[bis(2- hydroxyethyl)amino]pyridin-2(1H)-one 18 respectively. The preparation involved a tandem chlorination/cyclization reaction.

Synthesis and Evaluation of 2-Pyridinone Derivatives as HIV-1-Specific Reverse Transcriptase Inhibitors. 2. Analogues of 3-Aminopyridin-2(1H)-one

A series of nonnulceoside 3-aminopyridin-2(1H)-one derivatives was synthesized and evaluated for HIV-1 RT inhibitory properties.Several analogs proved to be potent and highly selective antagonists with in vitro IC50 values as low as 19 nM in the enzyme assay using rC*dG as template*primer.Two compounds from this series, 3-amino>-5-ethyl-6-methylpyridin-2(1H)-one (34, L-697,639) and the corresponding 4,7-dichloro analogue (37, L-697,661) inhibited the spread of HIV-1 IIIb infection by 95percent in MT4 cell culture at concentrations of 25-50 nM and were selected for clinical trials as antiviral agents.

Cardiotonic Agents. 1. Synthesis and Structure-Activity Relationships in a New Class of 3-,4-, and 5-Pyridyl-2(1H)-quinolone Derivatives

A series of 3-,4-, and 5-pyridyl-2(1H)-quinolone derivatives with H or HO or CH3O substituents in the 8-position were prepared and tested for positive inotropic activity.Several derivatives, especially 29, 9b, and 27 with a pyridyl ring in the 5-position,

2-METHYL-4-(o-NITROBENZYLIDENE)OXAZOL-5-ONES

The cis and trans isomers of 2-methyl-4-(o-nitrobenzylidene)oxazol-5-one have been obtained.On reduction, the cis isomer formed 3-acetamidoquinolin-2-ol, and the trans isomer formed 4-(o-aminobenzylidene)-2-methyloxazol-5-one.Details of the IR, UV, PMR, a