5873-00-7

Basic information

• Product Name: 3-Aminoquinoline-2(1H)-one
• Synonyms: 3-Amino-2(1H)-quinolinone;3-Aminoquinoline-2(1H)-one;3-aminoquinolin-2(1H)-one;3-aMinoquinolin-2-ol
• CAS NO: 5873-00-7
• Molecular Formula: C₉H₈N₂O
• Molecular Weight: 160.17
• Mol File: 5873-00-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 285℃ (ethanol )
• Boiling Point: 409.909 °C at 760 mmHg
• Flash Point: 201.706 °C
• Appearance: /
• Density: 1.255 g/cm³
• CAS DataBase Reference: 3-Aminoquinoline-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Aminoquinoline-2(1H)-one(5873-00-7)
• EPA Substance Registry System: 3-Aminoquinoline-2(1H)-one(5873-00-7)

Safety Data

• Hazardous Substances Data: 5873-00-7(Hazardous Substances Data)

Usage

General Description

3-Aminoquinoline-2(1H)-one, also known as 1-aminoisoquinoline-2(1H)-one, is a heterocyclic compound with the molecular formula C9H8N2O. It is a derivative of quinoline and is a weakly basic compound that is used in organic synthesis and medicinal chemistry. 3-Aminoquinoline-2(1H)-one has been studied for its potential pharmacological properties, including its anti-inflammatory and anti-cancer activities. It has also been used as a building block for the synthesis of various bioactive compounds. Additionally, it has been investigated for its potential role in the treatment of malaria due to its ability to inhibit the growth of Plasmodium falciparum, the parasite responsible for the disease.

Upstream product

• 16551-96-5 3-Amino-1-hydroxy-1H-chinolin-2-on 
• 529-23-7 o-aminobenzaldehyde 
• 939-16-2 3-bromoquinolin-2-one 
• 5344-90-1 2-Aminobenzyl alcohol 
• 552-89-6 2-nitro-benzaldehyde 
• 6635-81-0 3-benzoylamino-1,2-dihydro-quinoline-2-one 
• 103029-75-0 3-nitroquinolin-2(1H)-one 
• 98293-45-9 cis-2-methyl-4-(o-nitrobenzylidene)oxazol-5-one 
• 833-62-5 N-(2-hydroxyquinolin-3-yl)acetamide 
• 335649-85-9 3-iodoquinolin-2-ol 

Downstream Products

• 116632-54-3 2-chloro-3-aminoquinoline 
• 872322-72-0 tert-butyl {(1R)-1-(2-fluorobenzyl)-3-oxo-3-[(2-oxo-1,2-dihydroquinolin-3-yl)amino]propyl}carbamate 

Relevant articles and documents

An improved method for the synthesis of 3-amino-1H-quinolin-2-one

An efficient method for the synthesis of 3-amino-1H-quinolin-2-one is described. Condensation of o-nitrobenzaldehyde with hippuric acid gave 4-(2-nitrobenzylidene)-2-phenyloxazol-5-one. This compound was reduced to give 4-(2-aminobenzylidene)-2-phenyloxaz

Synthesis of 4-(2-chloroethyl)-2,3-dihydro[1,4]oxazino[2,3-b]quinoline and 4-(2-chloroethyl)-2,3-dihydropyrido[2,3-b][1,4]oxazine

The title compounds were synthesized from 3-[bis(2- hydroxyethyl)amino]quinolin-2(1H)-one 11a and 3-[bis(2- hydroxyethyl)amino]pyridin-2(1H)-one 18 respectively. The preparation involved a tandem chlorination/cyclization reaction.

Cardiotonic Agents. 1. Synthesis and Structure-Activity Relationships in a New Class of 3-,4-, and 5-Pyridyl-2(1H)-quinolone Derivatives

A series of 3-,4-, and 5-pyridyl-2(1H)-quinolone derivatives with H or HO or CH3O substituents in the 8-position were prepared and tested for positive inotropic activity.Several derivatives, especially 29, 9b, and 27 with a pyridyl ring in the 5-position,