58751-78-3Relevant articles and documents
Thermal Valence Rearrangements of Heterocycles. Part 2. A New Synthetic Approach Towards the Indole Ring System
Bennett, Grace A.,Mullen, George B.,Georgiev, Vassil St.
, p. 1718 - 1721 (1989)
A new synthetic approach towards the indole ring system is described. When dimethyl 1-methyl-2-oxa-1-azaspirodec-3-ene-3,4-dicarboxylate (6) was refluxed in toluene, the previously known dimethyl 4,5,6,7-tetrahydro-1-methyl-1H-indole-2,3-dicarboxylat
Tin-free radical alkylation of ketones via N-silyloxy enamines
Song, Hyun-Ji,Lim, Che Jo,Lee, Sunggi,Kim, Sunggak
, p. 2893 - 2895 (2008/09/18)
The radical alkylation of ketones is achieved by their conversion into corresponding N-silyloxy enamines, followed by a radical reaction with alkyl halides bearing electron-withdrawing groups. The Royal Society of Chemistry 2006.
Reaction of Oximes with Dimethyl Carbonate: A New Entry to 3-Methyl-4,5-disubstituted-4-oxazolin-2-ones
Marques, C. A.,Selva, M.,Tundo, P.,Montanari, F.
, p. 5765 - 5770 (2007/10/02)
The reaction of ketone oximes with dimethyl carbonate (DMC) carried out in an autoclave at 180-190 deg C and in the presence of K2CO3 yields 3-methyl-4,5-disubstituted-4-oxazolin-2-ones.The reaction can be applied to both aliphatic and aromatic ketone oximes, provided that a methylene group be present near the C=N bond.Nonoptimized yields range from 22 to 48percent.The reaction seems to be a sigmatropic rearrangement where DMC plays a key role in causing the initial N-methylation of the oximes.