58752-01-5

Upstream product

• 107-29-9 Acetaldehyde oxime 
• 4652-27-1 4-methoxy-3-buten-2-one 
• 79-24-3 Nitroethane 
• 51731-17-0 trans-4-methoxy-3-buten-2-one 
• 496870-91-8 N-methoxy-N,3-dimethylisoxazole-4-carboxamide 
• 75-16-1 methylmagnesium bromide 
• 17153-20-7 3-methyl isoxazole-4-carboxylic acid 

Downstream Products

• 59986-36-6 2-bromo-1-(3-methyl-isoxazol-4-yl)-ethanone 
• 1616100-92-5 (R)-N-((S)-2-(2,4-difluorophenyl)-4-(3-methylisoxazol-4-yl)-4-oxobutan-2-yl)-2-methylpropane-2-sulfinamide 
• 1616100-93-6 (R)-N-((2S,4R)-2-(2,4-difluorophenyl)-4-hydroxy-4-(3-methylisoxazol-4-yl)butan-2-yl)-2-methylpropane-2-sulfinamide 
• 1616100-94-7 (1R,3S)-3-amino-3-(2,4-difluorophenyl)-1-(3-methylisoxazol-4-yl)butan-1-ol 
• 1616100-95-8 N-(((2S,4R)-2-(2,4-difluorophenyl)-4-hydroxy-4-(3-methylisoxazol-4-yl)butan-2-yl)carbamothioyl)benzamide 

Relevant academic research and scientific papers

4,6-DIARYLAMINOTHIAZINES AS BACE1 INHIBITORS AND THEIR USE FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION

Compounds of formula (I), including pharmaceutically acceptable salts thereof, are set forth herein: (I) wherein R1 and R2 are independently hydrogen, or -CH3; or R1 and R2 can join together in a ring by adding -(CH2)4-; R3 is hydrogen or C1-C3 al-kyl; Y and Z are independently a C6-C10- aryl group or a 5-10 membered heterocyclic group which can be further substituted with from 0-3 substituents selected from the group of halogen, hydroxy, amino, C1-4 alkylamino, C1-4 dialkylamino, halo C1-4 alkyl, CN, C1-C6, alkyl or cycloalkyl, C1-C6 alkoxy, -C=OC1-4 alkyl, -SO2C1-4 alkyl, and C2-C4 alkynyl; A is selected from the group of phenyl, ben-zyl, oxazolyl, thiazolyl, isoxazolyl, imidazolyl, pyrazolyl, pyridyl, pyrimidinyl, and pyrazinyl groups which can be further substituted with from 0-3 substituents selected from the group of halogen, hydroxy, amino, C1-4 alkylamino, C1-4 dialkylamino, haloC1-4 alkyl, hydroxyC1-6 alkyl, CN, C1-C6 alkyl or cycloalkyl, C1-C6 alkoxy, and C2-C4 alkynyl; L is -NHCO-, or is a single bond; and L and Z to-gether can be absent

Regioselective synthesis of 4-acetyl- and 5-acetyl-3-methylisoxazole: Their conversion into silyl- and methyl enol ethers

Acetonitrile oxide reacts regioselectively with 3-buten-2-one and (E)-4-methoxy-3-buten-2-one to give 5-acetyl- 2 and 4-acetyl-3-methylisoxazole 3, respectively. Treatment of ketones 2 and 3 with trimethylsilyl trifluoromethanesulfonate gave the silyl enol ethers 4 and 5, whereas the methyl enol ethers 8 and 9 were obtained via elimination of methanol from the corresponding dimethyl ketals.

N-(4-isoxazolylthiazol-2-yl)oxamic acid derivatives as potent orally active antianaphylactic agents

A series of N-(4-isoxazolylthiazol-2-yl)oxamic acid derivatives was synthesized and tested on the passive cutaneous anaphylaxis (PCA) model in rats to verify its potential antianaphylactic activity. These compounds were prepared by reaction of an appropri