58755-08-1

Usage

Uses

Used in Pharmaceutical Industry:
(5E)-5-(4-methoxybenzylidene)-2-phenyl[1,3]thiazolo[3,2-b][1,2,4]triazol-6(5H)-one is used as a potential candidate for the development of new drugs due to its unique structural features and potential biological activities. It may be utilized in the treatment of various diseases and conditions, pending further research and studies to fully understand and harness its potential in medicine and pharmacology.

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 79-11-8 chloroacetic acid 
• 3414-94-6 3-phenyl-4,5-dihydro-1H-1,2,4-triazole-5-thione 
• 98-88-4 benzoyl chloride 
• 58755-01-4 <(3-Phenyl-1,2,4-triazolo-5-yl)thio>essigsaeure 
• 5351-66-6 benzoyl thiosemicarbazide 

Relevant academic research and scientific papers

Synthesis and evaluation of anti-inflammatory activity of some thiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones and their Michael addition products

Thiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones (4-10) were obtained in a one step synthesis by heating 3-aryl-5-mercapto-1,2,4-triazoles (3a-d) with chloroacetic acid and appropriate aromatic aldehyde in acetic acid and acetic anhydride in the presence of anhydrous NaOAc. Michael type addition of cyclic secondary amines (N-methylpiperazine, piperidine) to 4-10 gave 2-phenyl-6- (α-aminoarylmethyl)thiazolo[3,2-b]-1,2,4-triazole-5-ols (4a-10b). The structures of the compounds were confirmed by spectral and elementary analysis. The compounds synthesized in previous and present studies were investigated for their anti-inflammatory activities.