58758-37-5

Basic information

• Product Name: 6-chloro-2-(4-methylphenyl)benzoxazole
• Synonyms: 6-chloro-2-(4-methylphenyl)benzoxazole
• CAS NO: 58758-37-5
• Molecular Weight: 243.692
• Mol File: 58758-37-5.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 6-chloro-2-(4-methylphenyl)benzoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-2-(4-methylphenyl)benzoxazole(58758-37-5)
• EPA Substance Registry System: 6-chloro-2-(4-methylphenyl)benzoxazole(58758-37-5)

Safety Data

• Hazardous Substances Data: 58758-37-5(Hazardous Substances Data)

Upstream product

• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 36719-51-4 3,3-diethyl-1-(4-methylphenyl)-1-triazene 
• 31928-44-6 2-bromo-4-chloroiodobenzene 
• 619-55-6 para-methylbenzamide 
• 33667-89-9 N-(4-chlorophenyl)-4-methylbenzamide 
• 104-87-0 4-methyl-benzaldehyde 
• 28443-50-7 2-amino-5-chlorophenol 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 95-55-6 2-amino-phenol 
• 99-94-5 p-Toluic acid 
• 835-71-2 2-(4-methylphenyl)-1,3-benzoxazole 
• 54367-80-5 7-chloro-3-p-tolyl-2⁽⁴⁾H-benzo[1,2,4]oxadiazine 

Relevant articles and documents

Copper-catalysed intramolecular O-arylation: A simple and efficient method for benzoxazole synthesis

A wide range of 2-substituted benzoxazoles can be efficiently synthesized from N-(2-iodo-/bromo-phenyl)benzamides, and even the less reactive N-(2-chlorophenyl)benzamides, via Cu-catalysed intramolecular coupling cyclization reactions using methyl 2-methoxybenzoate as the ligand under mild reaction conditions. In addition, the benzoxazoles can be easily prepared from the primary amides coupling with o-dihalobenzenes in a single step. This journal is

Palladium-catalyzed direct C2-arylation of azoles with aromatic triazenes

A highly efficient palladium-catalyzed arylation of azoles at the C2-position using 1-aryltriazenes as aryl reagents was developed. Azoles including oxazoles, thiazoles, imidazoles, 1,3,4-oxadiazoles, and oxazolines could react with 1-aryltriazenes smoothly to generate the corresponding products in good to excellent yields, and various substitution patterns were tolerated toward the reaction.

Iron-catalyzed 2 - benzenes and wicked zuozuo apperception for the synthesis of the new method

The invention discloses a new synthesis method of iron-catalyzed 2-aryl benzoxazoles, which is prepared by directly performing C-N coupling and C-O coupling on benzamide and o-bromoiodobenzene serving as raw materials at a certain temperature in the presence an iron salt, a ligand and an alkali. According to the invention, a biological metal iron is introduced in synthesis of medical skeletons 2-aryl benzoxazoles, thus use of high-toxicity metals like palladium is avoided, and the application range of the method is expanded to substrates containing different substituent groups. The invention also successfully develops a catalyzing system which can have a catalysis effect on C-N and C-O coupling at the same time, and can greatly improve the safety of 2-aryl benzoxazoles in the synthesis process.