58775-91-0Relevant academic research and scientific papers
Derivative with imidazopyridine, preparation method and application in medicine thereof
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Paragraph 0084; 0085; 0086; 0120; 0122; 0123, (2017/08/24)
The invention discloses a derivative with imidazopyridine, a preparation method and application in medicine thereof. Concretely speaking, the invention relates to a novel derivative, medicinal salt of the derivative or pharmaceutical compositions containing the derivative, and the preparation method of the derivative showed in general formula (I). The invention also discloses application of the derivative, medicinal salt of the derivative or pharmaceutical compositions containing the derivative in Bruton tyrosine kinase inhibitor, preparing the medicine for treating or preventing tumor and inflammation diseases. Substituent groups in general formula (I) are identical to definitions in the specification (the structure is shown in the description).
Derivative having imidazopyrazines, preparation method and application thereof of derivative on medicine
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Paragraph 0090; 0091; 0092; 0132; 0133; 0134, (2017/08/27)
The invention discloses a derivative having imidazopyrazines, a preparation method and an application thereof of the derivative on medicine. Concretely speaking, the invention relates to a novel derivative shown in a general formula (I) and its medicinal salt or a pharmaceutical composition containing the derivative, and its preparation method. The invention also discloses the derivative or its medicinal salt or an application of the pharmaceutical composition containing the derivative in a Bruton tyrosine kinase inhibitor, and in preparation of medicines for treating and/or preventing diseases such as tumour and inflammation. The substituent in the formula (I) has same definition in the specification.
Pyrazole-5-carboxamides, novel inhibitors of receptor for advanced glycation end products (RAGE)
Han, Young Taek,Kim, Kyeojin,Choi, Gyeong-In,An, Hongchan,Son, Dohyun,Kim, Hee,Ha, Hee-Jin,Son, Jun-Hyeng,Chung, Suk-Jae,Park, Hyun-Ju,Lee, Jeewoo,Suh, Young-Ger
, p. 128 - 142 (2014/05/06)
In an effort to develop novel inhibitors of receptor for advanced glycation end products (RAGE) for the treatment of Alzheimer's disease, a series of pyrazole-5-carboxamides were designed, synthesized and biologically evaluated. Analyses of the extensive
SAR-based optimization of a 4-quinoline carboxylic acid analogue with potent antiviral activity
Das, Priyabrata,Deng, Xiaoyi,Zhang, Liang,Roth, Michael G.,Fontoura, Beatriz M.A.,Phillips, Margaret A.,De Brabander, Jef K.
supporting information, p. 517 - 521 (2013/07/26)
It is established that drugs targeting viral proteins are at risk of generating resistant strains. However, drugs targeting host factors can potentially avoid this problem. Herein, we report structure-activity relationship studies leading to the discovery
