587832-07-3

Upstream product

• 67-56-1 methanol 
• 883749-81-3 (+)-2-[4-phenylmethoxy-phenoxy]-2-methyl butyric acid 
• 103-16-2 4-Benzyloxyphenol 
• 208117-20-8 methyl (2S)-2-hydroxy-2-methylbutanoate 

Downstream Products

• 653563-78-1 R-(+)-2-(4-hydroxyphenoxy)-2-methyl butyric acid methyl ester 

Relevant academic research and scientific papers

Stereospecific synthesis of chiral tertiary alkyl-aryl ethers via Mitsunobu reaction with complete inversion of configuration

Mitsunobu reaction of chiral tertiary alcohol (S)-2 with phenol 3 provides the desired ether (R)-1 in moderate yields at elevated temperatures (80-100°C). The SN2 displacement pathway is evident by complete inversion of the (S)-alcohol to (R)-e

Process for the preparation of optically pure isomers of 2-(4-hydroxy phenoxy)-2-methyl-butyric acid methyl ester

The invention provides a process for preparing R-(+)-2-(4-hydroxyphenoxy)-2-methyl-butyric acid methyl ester of the formula (1): Various embodiments and variants are provided. The invention also provides a process for preparing S-(?)-2-(4-hydroxyphenoxy)-

NOVEL ISOXAZOLE COMPOUNDS HAVING PPAR AGONIST ACTIVITY

The present invention relates to novel isoxazole compounds of formula (I) having (PPAR) agonist activity, pharmaceutical compositions containing such compounds and methods for their use.