58827-15-9

Basic information

• Product Name: N-(2-aminoethyl)thiophene-2-carboxamide
• Synonyms: N-(2-aminoethyl)thiophene-2-carboxamide;N-(2-AMINOETHYL)-2-THIOPHENECARBOXAMIDE;OTAVA-BB 1137842;N-(2-AMinoethyl)-2-thiophenecarboxaMide HCl
• CAS NO: 58827-15-9
• Molecular Formula: C₇H₁₀N₂OS
• Molecular Weight: 170.235
• Mol File: 58827-15-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-(2-aminoethyl)thiophene-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-aminoethyl)thiophene-2-carboxamide(58827-15-9)
• EPA Substance Registry System: N-(2-aminoethyl)thiophene-2-carboxamide(58827-15-9)

Safety Data

• Hazardous Substances Data: 58827-15-9(Hazardous Substances Data)

Upstream product

• 2810-04-0 Ethyl thiophene-2-carboxylate 
• 5271-67-0 2-Thiophenecarbonyl chloride 
• 57260-73-8 N-BOC-1,2-diaminoethane 
• 107-15-3 ethylenediamine 

Downstream Products

• 58827-35-3 Thiophene-2-carboxylic acid {2-[3-(2-carbamoyl-phenoxy)-2-hydroxy-propylamino]-ethyl}-amide 
• 58827-16-0 Thiophene-2-carboxylic acid [2-(2-hydroxy-3-phenoxy-propylamino)-ethyl]-amide 

Relevant articles and documents

Investigation of synergistic antimicrobial effects of the drug combinations of meropenem and 1,2-benzisoselenazol-3(2H)-one derivatives on carbapenem-resistant Enterobacteriaceae producing NDM-1

The worldwide prevalence of NDM-1-producing bacteria has drastically undermined the clinical efficacy of the last line antibiotic of carbapenems, prompting a need to devise effective strategy to preserve their clinical value. Our previous studies have shown that ebselen can restore the efficacy of meropenem against a laboratory strain that produces NDM-1. Here we report the construction of a focused compound library of 1,2-benzisoselenazol-3(2H)-one derivatives which comprise a total of forty-six candidate compounds. The structure-activity relationship of these compounds and their potential to serve as an adjuvant to enhance the antimicrobial efficacy of meropenem against a collection of clinical NDM-1-producing carbapenem-resistant Enterobacteriaceae isolates was examined. Drug combination assays indicated that these derivatives exhibited synergistic antimicrobial activity when used along with meropenem, effectively restoring the activity of carbapenems against the resistant strains tested in a Galleria mellonella larvae in vivo infection model. The mode of inhibition of one compound, namely 11_a38, which was depicted when tested on the purified NDM-1 enzyme, indicated that it could covalently bind to the enzyme and displaced one zinc ion from the active site. Overall, this study provides a novel 1,2-benzisoselenazol-3(2H)-one scaffold that exhibits strong synergistic antimicrobial activity with carbapenems, and low cytotoxicity. The prospect of application of such compounds as carbapenem adjuvants warrants further evaluation.

Anti-inflammatory esters of 4-(1-hydroxy-2-[(acylamino)alkylamino]ethyl) phenols

The invention concerns novel esters of 4-(1-hydroxy-2-[(acylamino)alkylamino]ethyl)phenols of the formula: STR1 and salts thereof, wherein R1 and R2 are (3-5C)alkyl, R3 and R4 are hydrogen or methyl, A is a dire