58844-73-8Relevant academic research and scientific papers
Copper(II)-catalyzed direct sulfonylation of C(sp2)-H bonds with sodium sulfinates
Rao, Wei-Hao,Shi, Bing-Feng
, p. 2784 - 2787 (2015)
A copper-catalyzed direct sulfonylation of C(sp2)-H bonds with sodium sulfinates using a removable directing group is described. This reaction tolerates a wide range of functional groups, providing an efficient protocol for the synthesis of diverse aryl sulfones. Moreover, a series of 2,6-disubstituted benzamides could be synthesized via sequential C-H functionalization.
Visible-Light Photoredox/Nickel Dual Catalysis for the Cross-Coupling of Sulfinic Acid Salts with Aryl Iodides
Liu, Nai-Wei,Hofman, Kamil,Herbert, André,Manolikakes, Georg
supporting information, p. 760 - 763 (2018/02/09)
An efficient cross-coupling of sodium or lithium sulfinates with aryl iodides, using a combination of nickel and photoredox catalysis, is described. The dual catalyst system enables a versatile synthesis of aryl sulfones at room temperature in good yields and displays a broad functional group compatibility. The potential utility of this method in the late-stage diversification of complex molecules and in the conversion of organolithium reagents and sulfur dioxide into sulfones is demonstrated.
Aromatic pyrrolidine amide prolyl endopeptidase inhibitors
-
, (2008/06/13)
A series of aromatic pyrrolidine derivatives and suitable pharmaceutically acceptable salts thereof are disclosed. These compounds are useful as PEP inhibitors in the treatment of Alzheimer's disease, amnesia, dementia, anxiety ischemia, or stroke.
