Copper(II)-catalyzed direct sulfonylation of C(sp2)-H bonds with sodium sulfinates

Article abstract of DOI:10.1021/acs.orglett.5b01198

A copper-catalyzed direct sulfonylation of C(sp²)-H bonds with sodium sulfinates using a removable directing group is described. This reaction tolerates a wide range of functional groups, providing an efficient protocol for the synthesis of diverse aryl sulfones. Moreover, a series of 2,6-disubstituted benzamides could be synthesized via sequential C-H functionalization.