58861-90-8

Basic information

• Product Name: 2-Methyl-5-phenylpyrazine
• Synonyms: 2-Methyl-5-phenylpyrazine
• CAS NO: 58861-90-8
• Molecular Formula: C₁₁H₁₀N₂
• Molecular Weight: 170.2105
• Mol File: 58861-90-8.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Methyl-5-phenylpyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-5-phenylpyrazine(58861-90-8)
• EPA Substance Registry System: 2-Methyl-5-phenylpyrazine(58861-90-8)

Safety Data

• Hazardous Substances Data: 58861-90-8(Hazardous Substances Data)

Upstream product

• 2065-66-9 methyl-triphenylphosphonium iodide 
• 58861-94-2 2-phenylpyrazine 4-oxide 
• 1074-12-0 phenylglyoxal hydrate 
• 44160-79-4 propylenediamine 
• 78-90-0 1,2-diaminopropan 
• 591-51-5 phenyllithium 
• 23229-26-7 2-5-dibromopyrazine 
• 934-56-5 trimethyl(phenyl)stannane 
• 108-88-3 toluene 
• 74-88-4 methyl iodide 
• 72875-88-8 3-chloro-5-methyl-2-phenyl-pyrazine 
• 917-54-4 methyllithium 
• 29460-97-7 2-phenylpyrazine 

Downstream Products

• 1373311-26-2 2-(bromomethyl)-5-phenylpyrazine 
• 1373311-05-7 2-((1H-imidazol-1-yl)methyl)-5-phenylpyrazine 

Relevant articles and documents

Method for site-selective alkylation of Diazine-N-oxide using phosphonium ylides

- N - Oxide (Diazine -)N-The position selective Oxides-C alkylation of H) relates to a method alkylation. To the present invention, a plurality of diazine compounds can be alkylated by selectively introducing an alkyl group to a diazine compound known as a core unit structure in a medicine, and synthesis of a plurality of diazine compounds (varenicline) paenibacillin A, which is a natural product, can be synthesized.

Cushing's syndrome: Development of highly potent and selective CYP11B1 inhibitors of the (pyridylmethyl)pyridine type

Potent and selective CYP11B1 inhibitors could be promising therapeutics for the treatment of Cushing's syndrome. Optimization of Ref 1 (5-((1H-imidazol-1- yl)methyl)-2-phenylpyridine) led to compound 44 (5-((5-methylpyridin-3-yl) methyl)-2-phenylpyridine) with a 50-fold improved IC50 value of 2 nM toward human CYP11B1 and an enhanced inhibition of the rat enzyme (IC 50 = 2440 nM) compared to Ref 1 (IC50 > 10000 nM). Furthermore, selectivities over CYP11B2, CYP17, and CYP19 were observed, as well as satisfying metabolic stability not only in human and rat plasma but also in liver S9 fraction. Investigation of cytotoxicity and inhibition of hepatic CYP2A6 and CYP3A4 showed that 44 fulfills first safety criteria and can be considered for further in vivo evaluation in rats.

Ladderlike oligomers; Intramolecular hydrogen bonding, push - pull character, and electron affinity

Symmetrical 2,5-bis(2-aminophenyl)pyrazines have been synthesized by application of the Stille coupling strategy. These cotrimers feature three important properties, namely strong intramolecular hydrogen bonding, push-pull character, and high electron aff