58876-62-3Relevant academic research and scientific papers
Synthesis, spectroscopic characterization, X-ray structure, and in vivo neurotropic activity of new 1,5-benzodiazepin-2-ones
Gaponov, Alexandr A.,Zlenko, Elena T.,Shishkina, Svetlana V.,Shishkin, Oleg V.,Antypenko, Oleksii M.,Tretiakov, Serhii V.,Palchikov, Vitaliy A.
, p. 1768 - 1780 (2016/10/03)
The paper reports the synthesis and in vivo pharmacological studies of a series of N-alkyl-1,5-benzodiazepine-2-ones. In this work, 19 novel benzodiazepine derivatives have been prepared and characterized by spectroscopic methods including 2D nuclear magnetic resonance techniques. Crystal structure of 1-benzyl-8-methyl-4-phenyl-1H-benzo[b][1,4]diazepin-2(3H)-one has also been determined by X-ray diffraction. Prediction of activity spectra for substances prediction and docking studies onto human serum albumin were conducted. Two compounds under these investigation showed high antihypoxic, tranquilizing, and anticonvulsant activity in vivo.
Enantioselective synthesis of 4-substituted 4,5-dihydro-1 H-[1,5]benzodiazepin-2(3 H)-ones by the Lewis base-catalyzed hydrosilylation
Chen, Xing,Zheng, Yongsheng,Shu, Chang,Yuan, Weicheng,Liu, Bo,Zhang, Xiaomei
experimental part, p. 9109 - 9115 (2011/12/16)
Enantioselective synthesis of 4-substituted 4,5-dihydro-1H-[1,5] benzodiazepin-2(3H)-ones has been accomplished through chiral Lewis base-catalyzed hydrosilylation. The corresponding products were obtained in excellent yields (up to 99%) and enantioselect
Condensed heterocyclic compounds, their production and use
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, (2008/06/13)
Compounds represented by the formula: STR1 wherein ring A is benzene; Ar is aromatic group; R1, R2 and R3 each stands for H, acyl, hydrocarbon or heterocyclic, or R2 and R3, taken together, may form non-aromatic cyclic hydrocarbon; X is methylene or carbonyl; ......... is single bond or double bond; when ......... is single bond, Y is --NR4 -- (R4 is H, acyl, hydrocarbon or heterocyclic), when ......... is double bond, Y is N; n is 1-3, provided that, X is carbonyl and, at the same time, R2 and R3, taken together, form non-aromatic cyclic hydrocarbon, ......... is double bond or R4 is a heterocyclic or --Z(CH2)m --W (Z is methylene or carbonyl, W is optionally substituted amino, and m denotes 0-5), or salts thereof have an excellent GnRH receptor antagonistic action and/or an action of improving sleep disturbances.
