58885-37-3

Usage

Uses

Used in Pharmaceutical Synthesis:
(R)-Methyl 2-aMino-3-(benzhydrylthio)propanoate is used as a precursor in the synthesis of pharmaceuticals and other organic compounds, playing a crucial role in the development of new drugs and therapeutic agents.
Used in Asymmetric Synthesis:
In the field of organic chemistry, (R)-Methyl 2-aMino-3-(benzhydrylthio)propanoate is utilized as a chiral ligand for asymmetric synthesis, enabling the production of enantiomerically pure compounds, which is essential for the creation of biologically active molecules.
Used in Medicinal Chemistry and Drug Discovery:
(R)-Methyl 2-aMino-3-(benzhydrylthio)propanoate is employed in medicinal chemistry and drug discovery for its potential to contribute to the design and synthesis of novel therapeutic agents, enhancing the development of more effective and targeted treatments for various diseases and conditions.

Upstream product

• 67-56-1 methanol 
• 5191-80-0 S-diphenylmethyl-L-cysteine 
• 18598-63-5 L-cysteine methyl ester hydrochloride 
• 90-99-3 diphenylchloromethane 

Downstream Products

• 1243149-41-8 C₂₇H₃₆N₂O₅S 
• 53907-25-8 C₃₁H₃₆N₂O₅S 

Relevant academic research and scientific papers

Synthesis and electrochemical studies of disubstituted ferrocene/dipeptide conjugates with sulfur-containing side chains

A series of 1 1'-disubstituted ferrocenoyl peptides incorporating dipeptide sidearms has been synthesized and studied electrochemically. The target peptides include ferrocene as an electrochemical reporter, sulfur-containing amino acids (L-methionine, S-methyl-L-cysteine, S-trityl-L-cysteine, S-benzhydryl-L- cysteine) as metal binding agents, and amino acids with non-polar side chains (L-alanine, L-valine, L-phenylalanine) as spacers between reporter and metal binding groups. Ferrocene/dipeptide conjugates were prepared using solution phase peptide synthesis methods employing a BOC-protecting group strategy and HBTU- (O-(benzotriazol-1-yl)-N, N, N', N'-tetramethyluronium hexafluorophosphate) mediated peptide coupling. The electrochemical properties of these 1, 1'-substituted ferrocenoyl peptides have been characterized using cyclic voltammetry. All exhibit fully reversible one electron oxidation steps; forward sweep half wave peaks (EF), reverse sweep half wave peaks (ER), peak separations (DEP) and half wave potentials (E1/2) are reported. Finally, towards the goal of utilizing ferrocenoyl peptides to detect heavy metals in solution, the response of these ferrocene/dipeptide conjugates to metal cations (zinc(II), mercury(II), cadmium(II), lead(II), silver(I)) has been examined. Monitoring changes in the potential of the Fe(II)/Fe(III) redox couple to follow peptide/metal interactions, we have probed the influence of the spacer unit between the redox reporter and the metal-binding amino acid, and shown that these systems respond to mercury(II) more strongly than to other heavy metal ions.

Aldehyde derivatives and their use as calpain inhibitors

Aldehyde derivatives with a specific calpain inhibiting activity and a platelet-aggregation inhibiting effect with formula (I) or formula (II): wherein R1 represents an aromatic hydrocarbon group, a heterocyclic group, or a group of-X-R3 in which X represents O,-S(O)m-(m = 0, 1, or 2), and R3 represents an aromatic hydrocarbon group, a heterocyclic group, or an alkyl group; Z represents R?-Y-or R?O-CH(R?)-in which Y represents a 3-to 7-membered nitrogen-containing saturated heterocyclic group, or a single cyclic saturated hydrocarbon group, R? represents an alkyl group, an alkenyl group, an alkynyl group, an acyl group, a sulfonyl group, an alkoxycarbonyl group, a carbamoyl group, or a thiocarbamoyl group, R? represents hydrogen, an alkyl group, or an aromatic hydrocarbon group, and R? represents an acyl group, a carbamoyl group, a thiocarbamoyl group, or an alkyl group; and n is an integer of 1 to 5. wherein R?, R?, R?, and R1? are defined in the specification.