58906-62-0

Usage

Uses

Used in Pharmaceutical Industry:
Dabigatran Impurity 22 is used as a reference material for the development and validation of analytical methods in the pharmaceutical industry. Its application is essential for the identification, quantification, and control of impurities in the synthesis process of Dabigatran Etexilate Mesylate, ensuring the quality and safety of the final drug product.
Additionally, understanding the properties and behavior of Dabigatran Impurity 22 can contribute to the optimization of the synthesis process, potentially leading to improved yields and reduced impurity levels. This, in turn, can enhance the overall efficacy and safety profile of Dabigatran Etexilate Mesylate as an antithrombotic agent.

Upstream product

• 75-44-5 phosgene 
• 623-37-0 n-hexan-3-ol 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 1610758-22-9 C₃₄H₄₁N₇O₅ 

Relevant academic research and scientific papers

Identification, synthesis, and strategy for the reduction of potential impurities observed in dabigatran etexilate mesylate processes

Synthetic impurities that are present in dabigatran etexilate mesylate were studied, and possible pathways by which these impurities are formed during the manufacturing process were examined. The impurities were monitored by high-performance liquid chromatography, and their structures were determined by mass spectrometry and 1H and 13C NMR. Potential causes for the formation of these impurities are discussed, and strategies to minimize their formation are also described.

1-(N-Octylthiocarbonyl)-2-(4-thiazolyl)benzimidazole

New benzimidazoles substituted at the 1-position with carbonyl substituents and at the 2-position with a 4-thiazolyl group are effective fungicides and anthelmintics. The compounds as well as processes for their preparation are described along with antifungal and anthelmintic compositions for their use. The 1-position substituent is a hydrocarbon group of from 5 to 12 carbon atoms connected to the carbonyl group through an oxygen or a sulfur atom. The compounds are generally prepared by contacting a 1-unsubstituted benzimidazole with a hydrocarbon radical substituted chloroformate or chlorothiol formate.