58910-31-9Relevant academic research and scientific papers
Preparation method of N-methylamine compound
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Paragraph 0094; 0095; 0096; 0099, (2017/08/19)
The invention discloses a preparation method of a N-methylamine compound. The preparation method comprises the following steps: under an inertia organic solvent or solvent-free condition and under a support-type nano-sized gold catalyst effect, a primary amine compound or a secondary amine compound is subjected to a N-methylation reaction with carbon dioxide and hydrogen to obtain the product. The preparation method takes CO2 as a methyl source, takes hydrogen as a reducing agent, and takes the support-type nano-gold as a catalyst, and has the advantages that process is simple, catalyst activity is high, reaction rate is fast, the catalyst recovery and utilization are convenient, the application scope of a substrate is wide, the production cost is low, the benifit is high, the post-treatment is simple, repeatability is good, safe performance is high, and environmental protection is achieved, and the method is adapted to industrial production.
Direct Methylation of Amines with Carbon Dioxide and Molecular Hydrogen using Supported Gold Catalysts
Du, Xian-Long,Tang, Gao,Bao, Hong-Liang,Jiang, Zheng,Zhong, Xin-Hua,Su, Dang Sheng,Wang, Jian-Qiang
, p. 3489 - 3496 (2015/11/02)
The N-methylation of amines with CO2 and H2 is an important step in the synthesis of bioactive compounds and chemical intermediates. The first heterogeneous Au catalyst is reported for this methylation reaction with good to excellent yields. The average turnover frequency (TOF) based on surface Au atoms is 45 h-1, which is the highest TOF value ever reported for the methylation of aniline with CO2 and H2. Furthermore, the catalyst is tolerant toward a variety of amines, which includes aromatic, aliphatic, secondary, and primary amines. Preliminary mechanistic studies suggest that the N-alkyl formamide might be an intermediate in the N-methylation of amine process. Moreover, through a one-pot process, it is possible to convert primary amines, aldehydes, and CO2 into unsymmetrical tertiary amines with H2 as a reductant in the presence of the Au catalyst.
Triton B-mediated mild, convenient, and efficient method for the selective alkylation of cyclic secondary amines and thiols
Meshram,Reddy, B. Chennakesava,Goud, P. Ramesh
experimental part, p. 2297 - 2303 (2009/12/01)
Alkylation of cyclic secondary amines, thiols, and pyridazinones has been demonstrated with alkyl halides using Triton B as base and reaction medium.
